106916-72-7Relevant articles and documents
Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti-inflammatory drugs: Synthesis, kinetic and pharmacological evaluation
Sehajpal, Shikha,Prasad, Deo Nandan,Singh, Rajesh K.
, (2019)
Ketoprofen belongs to one of the most common nonsteroidal anti-inflammatory drugs (NSAIDs) but its clinical usefulness has been restricted due to the high incidence of gastrointestinal complications. The release of reactive oxygen species (ROS) in NSAIDs
Synthesis, characterization and physicochemical properties of new chiral quinuclidinol quaternary ammonium salts
Li, Ruoheng,Li, Zicheng,Song, Hang,Wang, Zhixia,Xu, Qiwei,Yao, Shun
, (2020)
A new series of chiral quaternary ammonium salts (QASs) were successfully synthesized and characterized by FT-IR, NMR and MS. The thermal stability and melting point (mp) of the chiral QASs were measured. Moreover, basic physicochemical properties of the
Solvent- and base-free dicyclohexylcarbodiimide-promoted esterifications
Streinz,Koutek,?aman
, p. 809 - 811 (2001)
N,N'-Dicyclohexylcarbodiimide/base-promoted esterification of carboxylic acids containing α-halogen atom(s) gave low yields of products when performed in a solvent. This failure was found to be due to the low stability of appropriate intermediates under t
Using chiral ionic liquid additives to enhance asymmetric induction in a Diels-Alder reaction
Goodrich,Nimal Gunaratne,Hall,Wang,Jin,Muldoon,Ribeiro,Pombeiro,Parvulescu,Davey,Hardacre
, p. 1704 - 1713 (2017)
A bis-oxazoline ligand has been complexed using Cu(ii) and Zn(ii) trifluoromethanesulfonate and a range of chiral ionic liquid (CIL) additives based on natural products were used as a co-catalyst for a Diels-Alder reaction. The catalytic performance of th
Synthesis, characterization and applications of some novel DMAP-based chiral ionic liquids
Singh, Avtar,Chopra, Harish Kumar
, p. 106 - 111 (2018)
A convenient and efficient procedure for the synthesis of some novel chiral ionic liquids (CILs) from 4-dimethylaminopyridinium cation has been reported. The synthesis of the CILs includes the treatment of optically active (?)-menthyl ester with 4-dimethy
New benzimidazolium-based chiral ionic liquids: Synthesis and application in enantioselective sodium borohydride reductions in water
Singh, Avtar,Chopra, Harish Kumar
, p. 448 - 453 (2016)
New chiral ionic liquids based on benzimidazolium salts have been synthesized from the reaction of (-)-menthol or (-)-borneol, chloroacetic acid and 1-methylbenzimidazole. The structures of these chiral ionic liquids have been confirmed from 1H
SYNTHESIS AND STRUCTURE OF AMINO ESTERS OF MENTHOL
Raikova, T. S.,Kalechits, G. V.,Manukov, E. N.,Vyalimyae, T. K.,Makhach, S. A.
, p. 526 - 529 (1981)
The conditions for the acylation of (-)-menthol with monochloroacetyl chloride have been studied.Amino esters of (-)-menthol have been obtained by the nuclephilic replacement of the chlorine in (-)-menthol monochloroacetate by residues of secondary amines
S-Substituted-2-mercaptobenzthiazolium-based chiral ionic liquids: efficient organocatalysts for enantioselective sodium borohydride reductions of prochiral ketones
Singh, Avtar,Chopra, Harish Kumar
, p. 414 - 418 (2017)
Novel chiral ionic liquids having chirality in their cationic part have been synthesized for evaluation of their catalytic potential as organocatalysts in sodium borohydride reduction of prochiral ketones to yield optically active secondary alcohols. The chiral ionic liquids have been synthesized from the reaction of (?)-menthol or (?)-borneol, chloroacetic acid and S-methyl/benzyl-2-mercaptobenzthiazole. The synthesized chiral ionic liquids have been characterized by 1H, 13C NMR and Mass spectrometry. Moderate to excellent enantiomeric excess (ee?>?99%) has been obtained in asymmetric sodium borohydride reduction of prochiral ketones using these salts as chiral catalysts.
Characterization of Enantiomeric Pairs of Optically Active 10-P-5 Phosphoranes with Asymmetry Only at Phosphorus
Kojima, Satoshi,Kajiyama, Kazumasa,Akiba, Kin-Ya
, p. 1785 - 1798 (1995)
Diastereomeric phosphoranes (o-OC(CF3)2C6H4)2P*CH2CO2-(-)-menthyl (3-RP and 3-SP) of which absolute stereochemistry was determined were treated with LiAlH4 to give (o-OC(CF3)2C6H4)2P*CH2CH2OH (4-RP and 4-SP) as the first optically active pair of enantiomeric phosphoranes of rigid stereochemistry with asymmetry only upon the pentacoordinate phosphorus atom.The high enantiomeric purities of the alcohols were confirmed by converting them to their (+)-MTPA esters.Furthermore, when diastereomeric phosphoranes (o-OC(CF3)2C6H4)2P*CH2NHC*HCH3Ph (10-RP and 10-SP) of which absolute stereochemistry was also determined were treated with MeLi the first optically active pair of enantiomeric P-H phosphoranes (o-OC(CF3)2C6H4)2P*H (2-RP and 2-SP) with asymmetry only upon the pentacoordinate phosphorus atom could be obtained.The high enantiomeric purities of the P-H phosphoranes were confirmed by converting each of them to their corresponding (-)-menthyl esters 3-RP and 3-SP.
Stereoselective oxidation of methyl phenyl sulfide in the presence of chiral ionic liquids
Akopyan,Rakhmanov,Grigor'Ev,Ryzhov,Tarakanova,Anisimov
, p. 1302 - 1307 (2014)
Several ionic liquids containing a chiral center either in the cation or in the anion have been prepared. They have been applied as catalysts and solvents for stereoselective oxidation of methyl phenyl sulfide to obtain the respective sulfoxide.