106916-72-7Relevant articles and documents
Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti-inflammatory drugs: Synthesis, kinetic and pharmacological evaluation
Sehajpal, Shikha,Prasad, Deo Nandan,Singh, Rajesh K.
, (2019)
Ketoprofen belongs to one of the most common nonsteroidal anti-inflammatory drugs (NSAIDs) but its clinical usefulness has been restricted due to the high incidence of gastrointestinal complications. The release of reactive oxygen species (ROS) in NSAIDs
Solvent- and base-free dicyclohexylcarbodiimide-promoted esterifications
Streinz,Koutek,?aman
, p. 809 - 811 (2001)
N,N'-Dicyclohexylcarbodiimide/base-promoted esterification of carboxylic acids containing α-halogen atom(s) gave low yields of products when performed in a solvent. This failure was found to be due to the low stability of appropriate intermediates under t
Synthesis, characterization and applications of some novel DMAP-based chiral ionic liquids
Singh, Avtar,Chopra, Harish Kumar
, p. 106 - 111 (2018)
A convenient and efficient procedure for the synthesis of some novel chiral ionic liquids (CILs) from 4-dimethylaminopyridinium cation has been reported. The synthesis of the CILs includes the treatment of optically active (?)-menthyl ester with 4-dimethy
SYNTHESIS AND STRUCTURE OF AMINO ESTERS OF MENTHOL
Raikova, T. S.,Kalechits, G. V.,Manukov, E. N.,Vyalimyae, T. K.,Makhach, S. A.
, p. 526 - 529 (1981)
The conditions for the acylation of (-)-menthol with monochloroacetyl chloride have been studied.Amino esters of (-)-menthol have been obtained by the nuclephilic replacement of the chlorine in (-)-menthol monochloroacetate by residues of secondary amines
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Sisido,K. et al.
, p. 4878 - 4881 (1961)
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Stereoselective oxidation of methyl phenyl sulfide in the presence of chiral ionic liquids
Akopyan,Rakhmanov,Grigor'Ev,Ryzhov,Tarakanova,Anisimov
, p. 1302 - 1307 (2014)
Several ionic liquids containing a chiral center either in the cation or in the anion have been prepared. They have been applied as catalysts and solvents for stereoselective oxidation of methyl phenyl sulfide to obtain the respective sulfoxide.
Catalytic Sc(OTf)3 mediated direct asymmetric aldol reaction of (?)-menthyl isothiocyanatoacetate with aldehydes by using (?)-menthol as chiral auxiliary
Bhangare, Dattatraya N.,Shinde, Rohit G.,Pawar, Pushpalata D.,Nikalje, Milind D.,Lokhande, Mahendra N.
supporting information, p. 1878 - 1882 (2021/05/27)
This method involves the direct asymmetric aldol reaction of (?)-menthyl isothiocyanatoacetate 5 with a variety of substituted aromatic aldehydes, which offers a convenient method for the synthesis of intermediate containing biologically relevant α-amino
Preparation method of Gboxin
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Paragraph 0022; 0031-0033; 0043-0045; 0054-0056, (2020/08/27)
The invention relates to a preparation method of Gboxin. The method comprises the following steps: reacting o-phenylenediamine with n-propanal; preparing 2-ethyl-1H-benzimidazole, carrying out N-alkylation reaction on 2-ethyl-1H-benzimidazole and chloroacetic acid-L-menthyl ester to generate 2-(2-ethyl-1H-benzimidazole) L-menthyl acetate, carrying out methylation by using iodomethane to generate abenzimidazolium salt, and finally, exchanging iodine ions into chloride ions by using chlorine ion exchange resin to obtain the final product Gboxin. The method has the advantages of short process route, mild conditions, simple operation and low equipment requirements, and the obtained product has the advantages of high purity and high yield, and is suitable for industrial production.