63254-60-4

Upstream product

• 158419-36-4 menthyl Cbz-glycinate 
• 130156-93-3 (2S,5R)-2-isopropyl-5-methyl cyclohexyl-2-azidoacetate 
• 145280-11-1 (1R,2S,5R)-2-(1-methylethyl)-5-methylcyclohexyl 2-<(tert-butoxycarbonyl)amino>acetate 
• 16832-20-5 (1R,2S,5R)-menthol bromoacetate 
• 2216-51-5 (-)-menthol 
• 7377-98-2 (-)-menthyl chloroacetate 

Downstream Products

• 145280-11-1 (1R,2S,5R)-2-(1-methylethyl)-5-methylcyclohexyl 2-<(tert-butoxycarbonyl)amino>acetate 
• 125423-96-3 [(1R,4R)-1,7,7-Trimethyl-bicyclo[2.2.1]hept-(2E)-ylideneamino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 158419-31-9 menthyl N-<1-tert-butyldimethylsilyl-2-azetidinone-4-carboxy>glycinate 
• 63254-50-2 L-menthyl diazoacetate 
• 125423-98-5 [(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 125423-98-5 [(1R,2R,5R)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3E)-ylideneamino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 93273-86-0 (-)-menthyl-2-benzoylamoniacetate 
• 130156-98-8 (1R,2S,5R)-menthyl-N-(diphenylmethylidene)-glycinate 
• 886116-87-6 (2S,3R,4R,5S)-3-Fluoro-5-phenyl-pyrrolidine-2,4-dicarboxylic acid 4-ethyl ester 2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 
• 886116-89-8 (2R,3S,4S,5R)-3-Fluoro-5-phenyl-pyrrolidine-2,4-dicarboxylic acid 4-ethyl ester 2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 
• 886116-88-7 (2S,3R,4R,5S)-5-(4-Cyano-phenyl)-3-fluoro-pyrrolidine-2,4-dicarboxylic acid 4-ethyl ester 2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 
• 886116-90-1 (2R,3S,4S,5R)-5-(4-Cyano-phenyl)-3-fluoro-pyrrolidine-2,4-dicarboxylic acid 4-ethyl ester 2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 
• 395074-01-8 (1R,2S,5R)-menthyl-2-(diphenylmethylideneamino)propenoate 
• 395074-10-9 1-(1R,2S,5R)-menthyl 3-ethyl (1S)-1-benzyloxycarbonylamino-3-cyclopentenedicarboxylate 

Relevant academic research and scientific papers

DERIVATIVES OF MENTHOL AND USES THEREOF

A compound that includes a menthol glycinate. The menthol glycinate includes a menthol connected to a glycine or glycine derivative, via an ester linkage. The groups on the N atom are referred to as R1 and R2, and R1 and R

First 1,3-dipolar cycloaddition of azomethine ylides with (E)-ethyl 3-fluoroacrylate: Regio- and stereoselective synthesis of enantiopure fluorinated prolines

Enantiopure fluorinated prolines with four chiral centers were obtained from 1,3-dipolar cycloaddition of azomethine ylides and (E)-ethyl 3-fluoroacrylate. Georg Thieme Verlag Stuttgart.

Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

Compound 1 was identified by high throughput screening as a novel PAI-1 inhibitor. Optimization of the B and C-segments of 1 resulted in a series of structurally simplified compounds with improved potency. The synthesis and SAR data of these compounds are presented here.

Synthesis and biological activities of conformationally restricted cyclopentenyl-glutamate analogues

An efficient method for preparing conformationally restricted cyclopentenyl-glutamate analogues in a regioselective and diastereoselective manner has been developed using a formal [3 + 2] cycloaddition reaction of dehydroamino acids. Methods for preparing optically active versions of these compounds have also been devised. Of these compounds, (S)-2 is an agonist at the mGlu5 (EC50 18 μM) and mGlu2 (EC50 45 μM) receptors.

Facile synthesis of a chiral auxiliary bearing the isocyanide group

A previous study synthesized a chiral auxiliary bearing the isocyanide functionality in six steps and with an oxazoline functionality. This paper discusses the synthesis of a chiral isocyanide possessing the easily cleaved menthoxy group. The synthesis pr

Studies on the Alkylation of Dipeptide Substrates

Alkylation of anions derived from dipeptides with a glycine at the C-terminus have been investigated.A hydrocarbon sedition in the N-terminal residue does impart some asymmetric induction.The use of a chiral ester derivative provides the potential for double asymmetric induction and good selectivity.With an aspartyl residue at the N-terminus, problems were encountered due to competing side reactions.The use of an azetidione could circumvent some of these, but the observed induction was not high.

A radical-organometallic glycine synthon. Preparation of homochiral heterocyclic α-amino acids

Co(Acac)2 reacts with (1) and (d)-menthyl N-BOC-2-bromoglycinates to give (1)- and (d)-menthyl N-BOC-3-acetylnorvalinates, which are converted into homochiral 2-(3,5-dimethyl-4-pyrazolyl)glycine and 2-(3,5-dimethyl)-4-isoxazolylglycine.

Semicorrin Metal Complexes as Enantioselective Catalysts. Part 2. Enantioselective Cyclopropane Formation from Olefins with Diazo Compounds Catalyzed by Chiral (Semicorrinato)copper Complexes)

Copper complexes of chiral, C2-symmetric semicorrin ligands were found to be efficient catalysts for the cyclopropane formation from olefins with diazo compounds.In the presence of 1 mol-percent of catalyst, alkyl diazoacetates reacted smoothly with termi