107496-54-8Relevant articles and documents
A practical synthesis of 3,3-difluorocyclobutane carboxylic acid
Elend, Dirk,Fengas, David,Fray, M. Jonathan
, p. 657 - 662 (2005)
We reported a straightforward, three step synthesis of 3,3- difluorocyclobutane carboxylic acid.
Multigram Synthesis of C 4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks
Melnykov, Kostiantyn P.,Granat, Dmitriy S.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Grygorenko, Oleksandr O.
, p. 4949 - 4957 (2018/12/13)
An approach for the multigram synthesis of 3,3-difluorocyclobutyl-substituted building blocks (including carboxylic acid, amines, alcohols, azide, trifluoroborate ketone) is described. It is shown that, in most cases, ethyl 3,3-difluorocyclobutanecarboxylate is a convenient common synthetic intermediate to obtain the target derivatives. For preparation of 3,3-difluorocyclobutanol or -cyclobutanone, an alternative pathway via reaction of dichloroketene and tert -butyl or benzyl vinyl ether should be applied.
Novel process for synthesizing 3, 3-difluorocyclobutyric acid
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Paragraph 0047-0050, (2017/04/20)
The invention provides a novel process for synthesizing 3, 3-difluorocyclobutyric acid. No fluorinating reagent like DAST is used, and the novel process is realized directly through three-step reaction, thereby being low in production cost and suitable for industrial production. The novel process has the advantages that yield is increased, and cost is lowered greatly; strong-acid hydrolysis of cyan is omitted, so that yield is increased, cost is lowered, and 'three wastes' are reduced; hydrogenation condition is changed, and original high-pressure reaction is changed into low-pressure reaction, so that reaction dangerousness is reduced, cost is lowered, and yield is increased.
