1086-02-8

Basic information

• Product Name: PYRIDINITRIL
• Synonyms: 2,6-dichlor-4-phenylpyridin-3,5-dicarbonitril;2,6-dichloro-4-phenyl-5-pyridinedicarbonitrile;2,6-dichloro-4-phenylpyridinedicarbonitrile-3,5;culvan;ddpp;it-3296;2,6-DICHLORO-4-PHENYLPYRIDINE-3,5-DICARBONITRILE;PYRIDINITRIL
• CAS NO: 1086-02-8
• Molecular Formula: C₁₃H₅Cl₂N₃
• Molecular Weight: 274.1
• EINECS: 214-119-2
• Mol File: 1086-02-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 203-204 °C
• Boiling Point: 447.3 °C at 760 mmHg
• Flash Point: 224.3 °C
• Appearance: /
• Density: 1.48 g/cm³
• Vapor Pressure: 3.4E-08mmHg at 25°C
• Refractive Index: 1.657
• PKA: -8.78±0.10(Predicted)
• CAS DataBase Reference: PYRIDINITRIL(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINITRIL(1086-02-8)
• EPA Substance Registry System: PYRIDINITRIL(1086-02-8)

Safety Data

• Hazardous Substances Data: 1086-02-8(Hazardous Substances Data)

Usage

Description

Pyridinitril, also known as pyridine-2-carbonitrile, is a colorless liquid chemical compound with the formula C6H4N2. It is soluble in water and has a strong odor reminiscent of pyridine. This versatile compound serves as a crucial precursor in the synthesis of various products, including pharmaceuticals, dyes, and agricultural chemicals. Additionally, it finds applications as a corrosion inhibitor in metalworking and as a solvent in the production of rubber and resins. Due to its potential harmful effects if ingested or inhaled, it is essential to exercise caution when handling this chemical.

Uses

Used in Pharmaceutical Industry:
Pyridinitril is used as a precursor in the synthesis of pharmaceuticals for its ability to contribute to the development of various medicinal compounds.
Used in Dye Industry:
In the dye industry, Pyridinitril is utilized as a precursor for the production of dyes, owing to its chemical properties that facilitate the creation of colorants.
Used in Agricultural Chemicals Industry:
Pyridinitril serves as a starting material in the synthesis of agricultural chemicals, playing a role in developing products that contribute to crop protection and enhancement.
Used in Metalworking Industry:
As a corrosion inhibitor in metalworking, Pyridinitril helps protect metals from degradation, extending the life and performance of metal components.
Used in Rubber and Resins Production:
Pyridinitril is employed as a solvent in the production of rubber and resins, where it aids in the manufacturing process and contributes to the final product's properties.

InChI:InChI=1/C13H5Cl2N3/c14-12-9(6-16)11(8-4-2-1-3-5-8)10(7-17)13(15)18-12/h1-5H

Upstream product

• 67720-42-7 2-hydroxy-6-amino-4-phenylpyridine-3,5-dicarbonitrile 
• 96583-92-5 6-amino-2-chloro-4-phenylpyridine-3,5-dicarbonitrile 

Downstream Products

• 157139-76-9 ethyl 3,5-diamino-4-phenyldithieno<3',2'-e:2,3-b>pyridine-2,6-dicarboxylate 
• 157139-77-0 ethyl 3,5-di(pyrrol-1-yl)-4-phenyldithieno<3',2'-e:2,3-b>pyridine-2,6-dicarboxylate 
• 157139-78-1 4-phenyl-2,6-di(pyrrolidine-1-carbonyl)-3,5-di(pyrrol-1-yl)dithieno<3',2'-e:2,3-b>pyridine 
• 1184935-24-7 3-amino-6-chloro-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 
• 1322622-18-3 2,6-bis(N,N-dimethylamino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-41-1 2-chloro-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-53-5 2-((1-benzylpiperidin-4-yl)amino)-6-chloro-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-56-8 2,6-bis((1-benzylpiperidin-4-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-22-8 2-((1-benzylpiperidin-4-yl)amino)-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-24-0 2-(((1-benzylpiperidin-4-yl)methyl)amino)-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-26-2 2-((2-(1-benzylpiperidin-4-yl)ethyl)amino)-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-28-4 2-((3-(1-benzylpiperidin-4-yl)propyl)amino)-6-(methyl(prop-2-yn-1-yl)amino)-4-phenylpyridine-3,5-dicarbonitrile 
• 1335032-31-9 2-((1-benzylpiperidin-4-yl)amino)-4-phenyl-6-(prop-2-yn-1-ylamino)pyridine-3,5-dicarbonitrile 
• 1456626-34-8 2-((2-(1-benzylpiperidin-4-yl)ethyl)amino)-6-chloro-4-phenylpyridine-3,5-dicarbonitrile 

Relevant articles and documents

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors

The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC50 (μM) DYRK1A = 11; CDK5 = 0.41; GSK-3 = 1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease.