109082-85-1

Basic information

• Product Name: 6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]-
• Synonyms: 6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]-;N,O-Ditrityl Ganciclovir
• CAS NO: 109082-85-1
• Molecular Formula: C₄₇H₄₁N₅O₄
• Molecular Weight: 739.85954
• Mol File: 109082-85-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 9.27±0.20(Predicted)
• CAS DataBase Reference: 6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]-(109082-85-1)
• EPA Substance Registry System: 6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]-(109082-85-1)

Safety Data

• Hazardous Substances Data: 109082-85-1(Hazardous Substances Data)

Usage

Uses

N,O-Ditrityl Ganciclovir is an Impurity of Ganciclovir (G235000), a sugar modified acyclic analogue of guanosine (G837900).

Upstream product

• 82410-32-0 ganciclovir 
• 76-83-5 trityl chloride 

Downstream Products

• 1219792-45-6 N,O-bistrityl-O-mesyl ganciclovir 
• 1219792-43-4 N-trytil-2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-3-trityloxy-1'-propanyl-2'-(S)-azido-3'-methylbutanoate 
• 1429306-18-2 C₅₂H₄₉N₅O₅ 
• 1429306-17-1 C₄₉H₄₃N₅O₅ 
• 88110-89-8 9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine 
• 175865-59-5 valganciclovir hydrochloride 
• 109061-20-3 Adamantane-1-carboxylic acid 2-[6-oxo-2-(trityl-amino)-1,6-dihydro-purin-9-ylmethoxy]-3-trityloxy-propyl ester 

Relevant articles and documents

Synthesis of valganciclovir hydrochloride congeners

Valganciclovir hydrochloride (1) is used for the treatment of cytomegalovirus (CMV) retinitis in patients with weakened immune systems. Valganciclovir hydrochloride is a hydrochloride salt of L-valyl ester of ganciclovir (2) that exists as a mixture of two diastereomers. According to the U.S. Food and Drug Administration specifications, the diastereomeric ratio of valganciclovir hydrochloride 1 should be maintained in the range 55:45 to 45:55. According to the U.S. Food and Drug Administration specifications, the diastereomeric ratio of valganciclovir hydrochloride 1 should be maintained in the range 55:45 to 45:55. During the process development of valganciclovir hydrochloride, six related substances (impurities) were observed along with the final active pharmaceutical ingredient. Among these six impurities, ganciclovir (2) and guanine (3) are the key starting materials and degraded impurities of ganciclovir, respectively. The remaining four impurities were identified as isovalganciclovir hydrochloride (4), methoxymethylguanine (5), O-acetoxy ganciclovir (6), and isovalarylganciclovir (7). The present work describes the synthesis and characterization of these four impurities.

PREPARATION OF VALGANCICLOVIR AND ITS SALTS

Processes for preparing valganciclovir and pharmaceutically acceptable salts thereof, as well as intermediates for the processes.

Synthesis and antiviral activity of various esters of 9-[1,3-dihydroxy-2-propoxy)methyl]guanine

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