109398-10-9

Basic information

• Product Name: 1,1-diphenyl-3-methylbutane-1,3-diol
• Synonyms: 1,1-diphenyl-3-methylbutane-1,3-diol
• CAS NO: 109398-10-9
• Molecular Weight: 256.345
• Mol File: 109398-10-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,1-diphenyl-3-methylbutane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-diphenyl-3-methylbutane-1,3-diol(109398-10-9)
• EPA Substance Registry System: 1,1-diphenyl-3-methylbutane-1,3-diol(109398-10-9)

Safety Data

• Hazardous Substances Data: 109398-10-9(Hazardous Substances Data)

Upstream product

• 558-30-5 2-methyl-1,2-epoxypropane 
• 119-61-9 benzophenone 
• 894-18-8 ethyl 3-hydroxy-3,3-diphenylpropanoate 
• 75-16-1 methylmagnesium bromide 
• 43108-74-3 3-hydroxy-3-methyl-1-phenyl-1-butanone 
• 917-64-6 methyl magnesium iodide 

Relevant articles and documents

DMSO-Enabled Selective Radical O?H Activation of 1,3(4)-Diols

Control of selectivity is one of the central topics in organic chemistry. Although unprecedented alkoxyl-radical-induced transformations have drawn a lot of attention, compared to selective C?H activation, selective radical O?H activation remains less explored. Herein, we report a novel selective radical O?H activation strategy of diols by combining spatial effects with proton-coupled electron transfer (PCET). It was found that DMSO is an essential reagent that enables the regioselective transformation of diols. Mechanistic studies indicated the existence of the alkoxyl radical and the selective interaction between DMSO and hydroxyl groups. Moreover, the distal C?C cleavage was realized by this selective alkoxyl-radical-initiation protocol.

Nucleophilic Addition of Lanthanoid Metal Umpoled Diaryl Ketones to Electrophiles

Ytterbium metal promoted cross-coupling reactions of diaryl ketones with a variety of electrophiles are described.Diaryl ketones treated with 1-2 equiv of Yb metal react smoothly with other ketones, nitriles, epoxides, CO2, etc., to give the corresponding unsymmetrical pinacols, α-hydroxy ketones, 1,3-diols, α-hydroxy carboxylic acids, etc., in good yields respectively.These reactions occur via nucleophilic addition of the intermediates 4a-c to electrophiles.Reaction of benzophenone (1a) with Yb metal is discussed in detail and some information on the composition of the intermediates of the reaction of diaryl ketones with Yb metal are also given.