894-18-8

Basic information

• Product Name: β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester
• Synonyms: 3-Hydroxy-3,3-diphenylpropanoic acid ethyl ester;3-Hydroxy-3,3-diphenylpropionic acid ethyl ester;β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester;Ethyl 3-hydroxy-3,3-diphenylpropanoate
• CAS NO: 894-18-8
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.323
• Mol File: 894-18-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 429.4°Cat760mmHg
• Flash Point: 178.5°C
• Appearance: /
• Density: 1.142g/cm³
• Vapor Pressure: 3.89E-08mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester(894-18-8)
• EPA Substance Registry System: β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester(894-18-8)

Safety Data

• Hazardous Substances Data: 894-18-8(Hazardous Substances Data)

Usage

General Description

β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester, also known as ethyl 2-hydroxy-2-phenylacetate, is a chemical compound used in the production of pharmaceuticals and perfumes. It is an ester of β-hydroxy-β-phenylpropionic acid, which possesses anti-inflammatory properties and is commonly used in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen. This chemical is also used in the fragrance industry for its sweet, floral aroma, making it a common ingredient in perfumes and personal care products.β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester is a versatile compound with applications in both the pharmaceutical and fragrance industries.

InChI:InChI=1/C17H18O3/c1-2-20-16(18)13-17(19,14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12,19H,2,13H2,1H3

Upstream product

• 119-61-9 benzophenone 
• 141-78-6 ethyl acetate 
• 105-36-2 ethyl bromoacetate 
• 17792-17-5 ethyl 3,3-diphenylacrylate 
• 495-40-9 propiophenone 
• 5331-17-9 1,1-diphenylbutan-1-ol 
• 100-58-3 phenylmagnesium bromide 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 105-39-5 chloroacetic acid ethyl ester 
• 64-17-5 ethanol 
• 64-19-7 acetic acid 

Downstream Products

• 872782-55-3 3-hydroxy-3,3-diphenyl-propionic acid p-toluidide 
• 109398-10-9 1,1-diphenyl-3-methylbutane-1,3-diol 
• 52481-82-0 5,5-diphenyl-oxazolidin-2-one 
• 4541-91-7 2-bromo-3,3-diphenyl-acrylic acid 
• 4541-88-2 α-Chlor-β.β-diphenyl-acrylsaeure 

Relevant articles and documents

DMSO-Enabled Selective Radical O?H Activation of 1,3(4)-Diols

Control of selectivity is one of the central topics in organic chemistry. Although unprecedented alkoxyl-radical-induced transformations have drawn a lot of attention, compared to selective C?H activation, selective radical O?H activation remains less explored. Herein, we report a novel selective radical O?H activation strategy of diols by combining spatial effects with proton-coupled electron transfer (PCET). It was found that DMSO is an essential reagent that enables the regioselective transformation of diols. Mechanistic studies indicated the existence of the alkoxyl radical and the selective interaction between DMSO and hydroxyl groups. Moreover, the distal C?C cleavage was realized by this selective alkoxyl-radical-initiation protocol.

3,4-diaryl maleimide derivative and preparation method and application thereof

The invention discloses a 3,4-diaryl maleimide derivative represented by a general formula I and a medicinal salt form thereof. The invention further discloses a preparation method of the mentioned 3,4-diaryl maleimide derivative and application of the 3,

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcohols has been developed using the same reagent combination of iodobenzene dichloride (PhICl2) and sodium azide (NaN3).