111863-65-1

Basic information

• Product Name: bis(N(6)-adenosyl)dodecane
• Synonyms: bis(N(6)-adenosyl)dodecane
• CAS NO: 111863-65-1
• Molecular Formula: C₃₂H₄₈N₁₀O₈
• Molecular Weight: 700.78572
• Mol File: 111863-65-1.mol

Chemical Properties

• Boiling Point: 1029.9°Cat760mmHg
• Flash Point: 576.7°C
• Appearance: /
• Density: 1.62g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.746
• PKA: 12.82±0.70(Predicted)
• CAS DataBase Reference: bis(N(6)-adenosyl)dodecane(CAS DataBase Reference)
• NIST Chemistry Reference: bis(N(6)-adenosyl)dodecane(111863-65-1)
• EPA Substance Registry System: bis(N(6)-adenosyl)dodecane(111863-65-1)

Safety Data

• Hazardous Substances Data: 111863-65-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C32H48N10O8/c43-13-19-23(45)25(47)31(49-19)41-17-39-21-27(35-15-37-29(21)41)33-11-9-7-5-3-1-2-4-6-8-10-12-34-28-22-30(38-16-36-28)42(18-40-22)32-26(48)24(46)20(14-44)50-32/h15-20,23-26,31-32,43-48H,1-14H2,(H,33,35,37)(H,34,36,38)/t19-,20-,23-,24-,25-,26-,31-,32-/m1/s1

Upstream product

• 63945-11-9 6-phthalimido-1-hexanol 

Relevant articles and documents

Synthesis of bridged dinucleosides

A series of di-(adenosin-N6-yl) alkanes (1b) - (11) has been prepared by reaction of the appropriate diaminoalkanes with 6-chloro-9-β-D-(2,3,5-tri-O-acetyl)-ribofuranosyl-purine (2) followed by ammonolysis. Alternatively, an analogous reaction with 6-chloro-9-β-D-(2,3-O-isopropylidene)-ribofuranosylpurine (3) produced an intermediate which could be phosphorylated at the 5′-position prior to hydrolytic removal of the isopropylidene group. 4-(1,2,4-Triazolo)-1-(β-D-2,3,5-tri-O-acetyl ribofuranosyl)-2(1H)-pyrimidone (7) was an effective intermediate for the preparation of di-(cytidin-N4-yl) alkanes (8a), (8b), and (8c) from the appropriate diaminoalkanes. The longer chain di-(adenosin-N6-yl) alkanes are very effective inhibitors of adenosine kinase. In addition an approach to the di-(adenosin-N6-yl) alkanes is described which should allow tritium labelling of the alkyl chain.