1120-87-2Relevant articles and documents
Unusual carbonyl...carbonyl interaction in supramolecular structures of silver(I) complexes with 2,6-pyridinediylbis(4-pyridinyl)methanone
Wan, Chong-Qing,Mak, Thomas C. W.
, p. 832 - 842 (2011)
A series of silver(I) complexes of a higher homologue of di-2-pyridyl ketone, 2,6-pyridinediylbis(4-pyridinyl)methanone (abbreviated as L), consisting of {[Ag(L)(BF4)]·H2O}∞ (1), {[Ag(L)(NO3)]·H2O}∞ (2), [Ag 3(L)2(NO2)3(H2O)] ∞ (3), [Ag(L)]2(PF6)2 (4), {[Ag(L)(CO2CF3)]2}∞ (5), [Ag(L)]2(SO3CF3)2 (6), and [Ag(L)]2(CO2CF2CF3)2 (7), have been synthesized and characterized. Complexes 1 and 2 are isomorphous helical polymers, 3 is a metallacycle featuring a trisilver(I) core, and 4-7 are isostructural complexes containing a common dinuclear [Ag2(L) 2]2+ metallacyclic skeleton. All complexes except 4 feature a common dominant intermolecular multipolar carbonyl...carbonyl interaction, which along with argentophilic Ag(I)...Ag(I), π...π, hydrogen-bonding, Ag...O=C, O(trifluoroacetate)...C= O as well as unconventional C=O...π and anion-π(pyridyl) interactions assemble the different coordination motifs (1-3, 5-7) into higher-dimensional frameworks. Three principal types of carbonyl...carbonyl interaction exhibiting antiparallel, sheared parallel, and perpendicular motifs are observed, and unusual supramolecular associations such as "...[C= O...C=O]n ..." (in 1-2 and 6) and "...[C= O...C=O...π]n..." (in 3) and "C=O...C=O...C=O" (in 7) are the novel structural features established in these complexes. The geometrical parameters and role of such noncovalent interactions in the construction of the present series of supramolecular metal-organic frameworks are discussed.
Electrophotochemical Ring-Opening Bromination oftert-Cycloalkanols
Yamamoto, Kosuke,Toguchi, Hiroyuki,Kuriyama, Masami,Watanabe, Shin,Iwasaki, Fumiaki,Onomura, Osamu
, p. 16177 - 16186 (2021/09/13)
An electrophotochemical ring-opening bromination of unstrainedtert-cycloalkanols has been developed. This electrophotochemical method enables the oxidative transformation of cycloalkanols with 5- to 7-membered rings into synthetically useful ω-bromoketones without the use of chemical oxidants or transition-metal catalysts. Alkoxy radical species would be key intermediates in the present transformation, which generate through homolysis of the O-Br bond in hypobromite intermediates under visible light irradiation.
Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)
Breinbauer, Rolf,Doler, Carina,Fuchs, Elisabeth,Grabner, Gernot F.,Mayer, Nicole,Melcher, Michaela-Christina,Migglautsch, Anna K.,Romauch, Matthias,Schweiger, Martina,Zechner, Rudolf,Zimmermann, Robert
supporting information, (2020/07/13)
High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure–activity relationship (SAR) studies of small molecule inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target.
