1121-79-5

Basic information

• Product Name: 3-Chloro-6-methylpyridazine
• Synonyms: 3-CHLORO-6-METHYLPYRIDAZINE;AKOS BBS-00001551;Chloro-6-methylpyridazine;3-Chloro-6-Methyl;6-Chloro-3-methylpyridazine;pyridazine, 3-chloro-6-methyl-;3-Chloro-6-methylpyridazi...;3-Chloro-6-methyl-1,2-diazine
• CAS NO: 1121-79-5
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• EINECS: -0
• Product Categories: Heterocycles;Halides;Pyrazines, Pyrimidines & Pyridazines;Pyridazine series;Pyrazines, Pyrimidines & Pyridazines;PyridazinesHeterocyclic Building Blocks;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridazines;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;v;alkyl chloride
• Mol File: 1121-79-5.mol

Chemical Properties

• Melting Point: 50 °C
• Boiling Point: 58 °C
• Flash Point: 134.7 °C
• Appearance: colorless to yellow liquid
• Density: 1.234 g/cm³
• Vapor Pressure: 0.023mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO, Methanol (Slightly)
• PKA: 1.26±0.10(Predicted)
• BRN: 108655
• CAS DataBase Reference: 3-Chloro-6-methylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-6-methylpyridazine(1121-79-5)
• EPA Substance Registry System: 3-Chloro-6-methylpyridazine(1121-79-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-43-41-38-22
• Safety Statements: 26-37/39-36/37-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1121-79-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-6-methylpyridazine is used as a key intermediate in the preparation of heterocyclic compounds, which serve as integrase inhibiting antiviral agents. These agents are crucial in the development of antiviral medications, providing a means to combat viral infections by inhibiting the integration of viral DNA into the host genome.
Used in Organic Synthesis:
3-Chloro-6-methylpyridazine is utilized as a reactant in nickel-catalyzed cross-coupling reactions with aromatic and heteroaromatic halides. This process allows for the formation of substituted aryland heteroaryl pyridazines, which are valuable building blocks in the synthesis of various pharmaceuticals and agrochemicals.
Used in Medicinal Chemistry:
3-Chloro-6-methylpyridazine can be employed in the synthesis of a p38MAP kinase inhibitor, which holds therapeutic potential in the treatment of autoimmune and inflammatory diseases. By targeting the p38MAP kinase pathway, this inhibitor may help regulate immune responses and alleviate symptoms associated with these conditions.

InChI:InChI=1/C5H5ClN2/c1-4-2-3-5(6)8-7-4/h2-3H,1H3

Upstream product

• 13327-27-0 6-Methylpyridazin-3(2H)-on 
• 10025-87-3 trichlorophosphate 
• 13327-27-0 3-hydroxy-6-methylpyridazine 

Downstream Products

• 17644-83-6 6-methyl-3-methoxypyridazine 
• 100373-87-3 (4-methoxy-benzyl)-(6-methyl-pyridazin-3-yl)-amine 
• 99843-93-3 (6-methyl-pyridazin-3-yl)-phenyl-amine 
• 1632-76-4 3-methylpyridazine 
• 18591-87-2 3-amino-6-methylpyridazine 
• 13327-27-0 6-Methylpyridazin-3(2H)-on 
• 5788-47-6 6-Methylpyridazin-3-thion 
• 38956-79-5 3-hydrazinyl-6-methylpyridazine 
• 5096-73-1 6-chloro-pyridazine-3-carboxylic acid 
• 17258-26-3 3-chloro-4,6-dimethylpyridazine 
• 81102-55-8 (6-Methyl-pyridazin-3-yl)-p-tolyl-acetonitrile 
• 73535-71-4 (6-Methyl-pyridazin-3-yl)-phenyl-acetonitrile 
• 77778-18-8 3-(3-hydroxy-1-propynyl)-6-methylpyridazine 
• 70873-35-7 2-methyl-7-(diethylamino)pyrrolo<1,2-b>pyridazine 

Relevant articles and documents

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