112110-16-4

Basic information

• Product Name: 5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester
• Synonyms: 5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester;Dimethyl 5-methylpyridine-2,3-dicarboxylate;5-Methyl-2,3-Pyridinedicarboxylic Acid Dimethyl Ester
• CAS NO: 112110-16-4
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209
• Mol File: 112110-16-4.mol

Chemical Properties

• Boiling Point: 292.18 °C at 760 mmHg
• Flash Point: 130.506 °C
• Appearance: /
• Density: 1.197
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform, DMSO (Slightly), Methanol (Slightly)
• PKA: -0.54±0.10(Predicted)
• CAS DataBase Reference: 5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester(112110-16-4)
• EPA Substance Registry System: 5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester(112110-16-4)

Safety Data

• Hazardous Substances Data: 112110-16-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester is used as a reagent for various chemical reactions and syntheses. Its unique structure allows it to participate in a range of organic transformations, making it a valuable compound in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester is used as an intermediate in the synthesis of certain drugs. Its ability to form esters and participate in organic reactions makes it a useful building block for the creation of new pharmaceutical compounds.
Used in Material Science:
5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester is also used in material science as a component in the development of new materials. Its chemical properties can be exploited to create novel materials with specific characteristics, such as improved stability or reactivity.
Used in Research and Development:
In research and development settings, 5-Methylpyridine-2,3-dicarboxylic acid dimethyl ester is used as a model compound for studying the properties and reactions of pyridine derivatives. This helps scientists understand the behavior of similar compounds and develop new synthetic strategies.

Upstream product

• 66064-57-1 (E)-1,1-dimethyl-2-(2-methylallylidene)hydrazine 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 16713-45-4 methacrolein dimethylhydrazone 
• 78-85-3 2-methylpropenal 
• 35073-82-6 dimethyl 2-chloro-3-oxobutanedioate 
• 67-56-1 methanol 
• 105151-48-2 diethyl 5-methylpyridine-2,3-dicarboxylate 

Downstream Products

• 53636-65-0 5-methyl-pyridine-2,3-dicarboxylic acid 
• 143382-03-0 5-(methoxymethyl)-2,3-pyridinedicarboxylic acid 
• 104098-48-8 imazapic 

Relevant articles and documents

Preparation method of dimethyl 5-methoxymethyl-2, 3-pyridinedicarboxylate

The invention relates to the field of pesticide synthesis, and discloses a preparation method of dimethyl 5-methoxymethyl-2, 3-pyridinedicarboxylate. The method comprises the steps of 1) in the presence of alkali, carrying out transesterification on dimethyl 5-methyl-2, 3-pyridinedicarboxylate and methanol; 2) in the presence of an organic solvent, carrying out bromination reaction on the dimethyl 5-methyl-2, 3-pyridinedicarboxylate and a brominating agent to obtain a reaction product containing the dimethyl 5-methyl-2, 3-pyridinedicarboxylate, a monobromide, a dibromide and a tribromide; 3) performing quaternary ammonium salinization on the monobromide contained in the reaction product, and separating the monobromide from the reaction product subjected to quaternary ammonium salinization to obtain quaternary ammonium salt; and (4) enabling quaternary ammonium salt to be in contact with a sodium methoxide solution so as to obtain the dimethyl 5-methoxymethyl-2, 3-pyridinedicarboxylate. According to the method disclosed by the invention, few impurities are generated in the reaction process, and the steps are simple.

Preparation method for imidazolinone compound

The invention provides a preparation method for an imidazolinone compound, belongs to the technical field of organic synthesis, and can solve the problems that a large amount of wastewater is producedand the content of impurities in the product is high in the existing process for preparing the imidazolinone compound. According to the preparation method for the imidazolinone compound provided by the invention, a solution of 5-alkyl pyridine-2,3-phthalate is synthesized from ammonium carbonate; the steps of adding water, extracting, refining and the like are avoided in post-treatment; the obtained solution of the 5-alkyl pyridine-2,3-phthalate is used for subsequent reaction; and the wastewater is not produced. Then, a catalyst is added in the process of preparing 5-alkyl pyridine-2,3-dimethylbenzene anhydride, and the pH is controlled in the subsequent reaction process, so that the production of the impurities can be avoided, and the product purity is improved. The imidazolinone compound prepared by the method provided by the invention can be used as a high-efficiency herbicide.

Microwave-assisted Diels-Alder reaction supported on graphite

The coupling of graphite (as a support) with microwaves (as an energy source), a new type of "dry reaction", was studied for some Diels-Alder reactions involving anthracene and azadienes. Graphite is responsible for a high-temperature gradient leading to increased reaction rates as compared to conventional procedures using a solvent. VCH Verlagsgesellschaft mbH, 1996.

Ultrasound Assisted Diels-Alder Reactions of 1-Azadienes with "Normal" Electronic Demand.

Ultrasound irradiaton accelerates hetero Diels-Alder reactions between 1-dimethylamino-1-azadienes and electron-defficient dienophiles.Besides the lower reaction times and increased yields, other advantages of the sonicated reactions are the possibility of isolating previously unknown adducts due to the milder reaction conditions and, in some cases, the decrease in side reactions.

Process for the preparation of pyridine-2,3-dicarboxylic acid derivatives

A pyridine compound of formula I is prepared from a tetrahydropyridine compound of formula II in a single step or procedure under oxidising conditions. The R meanings are fully defined in the specification but preferably R1 and R3 represent hydrogen, R2, R11 and R12 represent alkyl, and R4 and R5 represent hydroxy or alkoxy or together represent -O- or -NR10- where R10 represents alkyl, cyanoalkyl, aminocarbonylalkyl or phenyl.