1122-20-9Relevant articles and documents
Direct C-nitration of cyclic α,β-unsaturated oximes under the action of sodium nitrite and acetic acid in methanol
Chibiryaev,Denisov,Pyshnyi,Tkachev
, p. 1410 - 1418 (2001)
Using a number of cyclic α,β-unsaturated oximes of the terpene series and some simplest model compounds as examples, unsaturated oximes bearing a hydrogen atom at the β-carbon atom were demonstrated to be converted into β-hydroxyiminonitroalkenes under the action of sodium nitrite and acetic acid in methanol. In the case of the introduction of an alkyl substituent at the terminal carbon atom of the diene C = C-C=NOH fragment, the reaction performed under the same conditions gave rise exclusively to conjugated ketone (a deoximation product).
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Bergmann,Weizmann
, p. 266,268 (1939)
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SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS
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Page/Page column 44; 45, (2008/12/04)
Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.
Selective iron-catalyzed cross-coupling reactions of Grignard reagents with enol triflates, acid chlorides, and dichloroarenes
Scheiper, Bodo,Bonnekessel, Melanie,Krause, Helga,Fuerstner, Alois
, p. 3943 - 3949 (2007/10/03)
Cheap, readily available, air stable, nontoxic, and environmentally benign iron salts such as Fe(acac)3 are excellent precatalysts for the cross-coupling of Grignard reagents with alkenyl triflates and acid chlorides. Moreover, it is shown that dichloroarene and -heteroarene derivatives as the substrates can be selectively monoalkylated by this method. All cross-coupling reactions proceed very rapidly under notably mild conditions and turned out to be compatible with a variety of functional groups in both reaction partners. A detailed analysis of the preparative results suggests that iron-catalyzed C-C bond formations can occur via different pathways. Thus, it is likely that reactions of methylmagnesium halides involve iron-ate complexes as the active components, whereas reactions of Grignard reagents with two or more carbon atoms are effected by highly reduced iron-clusters of the formal composition [Fe(MgX)2]n generated in situ. Control experiments using the ate-complex [Me4Fe]Li2 corroborate this interpretation.
