112827-99-3 Usage
Uses
(24R)-Calcipotriene is a synthetic analogs of vitamin D that was studied for its potential antitumor effects. Studies has shown the combined treatment with vitamin D analog (24R)-Calcipotriene was more effective than the treatment with cytostatics applied alone. (24R)-Calcipotriene is also the 24-R epimer of Calcipotriene (C144200).
Check Digit Verification of cas no
The CAS Registry Mumber 112827-99-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,8,2 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 112827-99:
(8*1)+(7*1)+(6*2)+(5*8)+(4*2)+(3*7)+(2*9)+(1*9)=123
123 % 10 = 3
So 112827-99-3 is a valid CAS Registry Number.
112827-99-3Relevant articles and documents
EPIMERIZATION OF ANALOGS OF VITAMIN D
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Page 16, (2008/06/13)
Provided is a method of general applicability of epimerizing a vitamin-D analog having an asymmetric allylic carbon atom at the C-24 position, which comprises the steps of: a) esterifying the hydroxyl group on the asymmetric allylic carbon atom at the 24 position with an esterifying agent, b) contacting a solution of the ester in a solvent with an epimerization-active solid, whereby the ester is epimerized, and c) hydrolysing the epimerized ester to obtain a mixture of C-24 epimers having a hydroxyl substituent on the asymmetric allylic carbon at position 24. The method is of particular utility in making calcipotriene.