112918-82-8

Basic information

• Product Name: N-FMOC-IMINODIACETIC ACID
• Synonyms: N-FMOC-IMINODIACETIC ACID 99+%;N-(9-Fluorenylmethoxycarbonyl)iminodiacetic acid;Fmoc-iminodiacetic acid≥ 99% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl Ida-OH
• CAS NO: 112918-82-8
• Molecular Formula: C₁₉H₁₇NO₆
• Molecular Weight: 355.34138
• Product Categories: Glycine Derivatives;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 112918-82-8.mol

Chemical Properties

• Melting Point: 213-217 °C
• Boiling Point: 618.4°C at 760 mmHg
• Flash Point: 327.8°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 3.77E-16mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C
• PKA: 3.33±0.10(Predicted)
• BRN: 7050417
• CAS DataBase Reference: N-FMOC-IMINODIACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-FMOC-IMINODIACETIC ACID(112918-82-8)
• EPA Substance Registry System: N-FMOC-IMINODIACETIC ACID(112918-82-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• F: 21
• HazardClass: IRRITANT
• Hazardous Substances Data: 112918-82-8(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C19H17NO6/c21-17(22)9-20(10-18(23)24)19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,21,22)(H,23,24)

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 142-73-4 iminodiacetic acid 

Relevant articles and documents

Chemical evidence for transbilayer movement of molecular umbrellas

Chemical evidence has been obtained for transbilayer movement of a di- walled and a tetra-walled molecular umbrella in large unilamellar vesicles (200 nm) derived from 1-palmitoyl-2-oleyol-sn-glycero-3-phoshatidylglycerol (POPG). A di-walled molecular umbrella (1), bearing 2-mercaptopyridine (2- MP) as a 'reactive tag', was synthesized by reaction of N1,N3- spermidinebis[cholic acid amide] (3) with [N-1,2,3-benzotriazin-4(3H)one- yl]-3-(2-pyridyldithio)propionate [BPDP]. An analogous tetra-walled umbrella (2) was also prepared by condensing Fmoc-protected iminodiacetic acid with two molecules of 3, deprotecting the secondary amino group, and coupling the resulting intermediate (4) with BPDP. Reaction of vesicle-bound 1 with external glutathione (GSH) resulted in a rapid and quantitative release of 2- MP. A similar thiolate - disulfide interchange reaction that was carried out between membrane-bound 1 and GSH, which was captured within the aqueous interior of the vesicles, also resulted in rapid and complete release of 2- MP. These results, together with the fact that GSH does not permeate across the POPG vesicle membranes, provides compelling evidence for rapid transbilayer movement. Reaction of membrane-bound 2 with external GSH also resulted in the rapid and quantitative release of 2-MP. The significance of these findings, with regard to the current view of molecular size restrictions on membrane permeability, is briefly discussed.

Structure-Activity Relationships of 1,3-Dialkylxanthine Derivatives at Rat A3 Adenosine Receptors

1,3-Dialkylxanthine analogues containing carboxylic acid and other charged groups on 8-position substituents were synthesized.These derivatives were examined for affinity in radioligand binding assays at rat brain A3 adenosine receptors stably

Adenosine receptor prodrugs

A functionalized congener approach to drugs acting at A 1 and A 2 adenosine receptor types is applicable to prodrug design. The prodrugs affect a more efficient delivery of the drug at the particular site of the body affected and take advantage of selective biochemical cleavages and alteration in distribution characteristics. In particular, kidney functions and lipid functions are stressed in the invention.