142-73-4Relevant academic research and scientific papers
Thermodynamic Parameters of Coupled Chemical Reactions from Temperature Jump Relaxation Amplitudes
Ushio, Hidetoshi,Trimm, Harold H.,Patel, Ramesh C.,Zemany, Michael D.
, p. 39 - 50 (1981)
Equations describing the temperature jump amplitudes associated with a system of two coupled reactions (TRIS - phenol red) as well as the ternary system (Mg(2+) - iminodiacetic acid - phenol red) are presented.The thermodynamic parameters calculated from experimentally measured temperature perturbation amplitudes using a multiparametric curve fitting procedure are found to be in good agreement with those determined from pH- and constant rate thermometric titrations.For phenol red, pKI = 7.55, ΔHI = 3.45 kcal, and for Mg(2+) iminodiacetic acid , logKM = 2.84, ΔHM = 3.25 kcal, were obtained.It is shown that this method can be used to determine accurate thermodynamic enthalpy changes over a narrow temperature interval of less than 1.0 deg C from a single experiment requiring about 50 μl of sample solution.
Biotransformation of iminodiacetonitrile to iminodiacetic acid by Alcaligenes faecalis cells immobilized in ACA-membrane liquid-core capsules
Zhang, Jin-Feng,Liu, Zhi-Qiang,Zhang, Xin-Hong,Zheng, Yu-Guo
, p. 53 - 64 (2014)
Biotransformation of iminodiacetonitrile (IDAN) to iminodiacetic acid (IDA) was investigated with a newly isolated Alcaligenes faecalis ZJUTBX11 strain showing nitrilase activity in the immobilized form. To reduce the mass transfer resistance and to increase the toleration ability of the microorganisms to the toxic substrate as well as to enhance their ability to be reused, encapsulation of the whole cells in alginate-chitosan-alginate (ACA) membrane liquid-core capsules was attempted in the present study. The optimal pH and temperature for nitrilase activity of encapsulated A. faecalis ZJUTBX11 cells were 7.5 C and 35 C, respectively, which is consistent with free cells. Based on the Michaelis-Menten model, kinetic parameters of the conversion reaction with IDAN as the substrate were: K m = (17.6 ± 0.3) mmol L-1 and V max = (97.6 ± 1.2) μmol min-1 g -1 of dry cell mass for encapsulated cells and (16.8 ± 0.4) mmol L-1 and (108.0 ± 2.7) μmol min-1 g -1 of dry cell mass for free cells, respectively. After being recycled ten times, the whole cells encapsulated in ACA capsules still retained 90 % of the initial nitrilase activity while only 35 % were retained by free cells. Lab scale production of IDA using encapsulated cells in a bubble column reactor and a packed bed reactor were performed respectively.
Highly efficient and stable bicomponent cobalt oxide-copper catalysts for dehydrogenation
Chen, Li,Duan, Zhengkang,Guo, Dongjie,Qiu, Tian,Ren, Shiyu,Wang, Yongsheng,Wu, Yingying,Xu, Weixiang,Zhang, Xinping
, (2020)
Cu/Co3O4-ZrO2 catalyst was synthesized by a simple co-precipitation method, and its self-oxidation behavior after reduction reduced the particle size of Co3O4. Cu/Co3O4-ZrO2 demonstrated a high performance during the dehydrogenation of diethanolamine, reaching a 96% yield of iminodiacetic in 30 min. The catalyst was characterized by XRD, XPS, TEM, SEM, and H2-TPR. The results showed that strong Cu-oxide interactions, the co-catalysis of biactive components, and the higher number of oxygen vacancies of Cu/Co3O4-ZrO2 were responsible for the enhanced catalytic activity during diethanolamine dehydrogenation. Co3O4 particles improved the dispersion and stability of Cu NPs and inhibited the sintering of loaded Cu NPs.
A ZrO2-RGO composite as a support enhanced the performance of a Cu-based catalyst in dehydrogenation of diethanolamine
Wang, Yongsheng,Zhao, Zhenzhen,Zhao, Yunlu,Lan, Xiaolin,Xu, Weixiang,Chen, Li,Guo, Dongjie,Duan, Zhengkang
, p. 30439 - 30447 (2019)
The sintering resistance of supported Cu nanoparticle (NP) catalysts is crucial to their practical application in the dehydrogenation of diethanolamine (DEA). In this paper, co-precipitation, hydrothermal synthesis, and sol-gel condensation are used to form a new support material through chemical bonding between graphene oxide and ZrO2. The composite carriers prepared by the three methods are mixed with copper nitrate and ground using a ball mill. A series of Cu/ZrO2-reduced graphene oxide (RGO) composites were prepared by calcination under nitrogen at 450 °C for 3 h and hydrogen reduction at 250 °C for 4 h. The conversion of DEA to iminodiacetic acid (IDA) reached 96% with the Cu/ZrO2-RGO catalyst prepared by hydrothermal synthesis. The conversion rate of DEA is more than 80% following the reuse of the CZG-2 catalyst for twelve cycles. The various physicochemical characterization techniques show that the Cu/ZrO2-RGO layered and wrinkled nanostructures can improve catalytic stability and suppress the sintering of the supported Cu NPs during the catalytic dehydrogenation of diethanolamine. A synergistic effect between the RGO and the Cu nanoparticles is observed. The Cu nanoparticles with RGO have a better dispersibility, and a new nano-environment is created, which is the key to improving the efficiency of diethanolamine dehydrogenation. These new Cu/ZrO2-RGO catalysts show increased durability compared to commercially produced Cu/ZrO2 catalysts and show promise for practical applications involving diethanolamine dehydrogenation.
A Zinc(II) Photocage Based on a Decarboxylation Metal Ion Release Mechanism for Investigating Homeostasis and Biological Signaling
Basa, Prem N.,Antala, Sagar,Dempski, Robert E.,Burdette, Shawn C.
, p. 13027 - 13031 (2015)
Metal ion signaling in biology has been studied extensively with ortho-nitrobenzyl photocages; however, the low quantum yields and other optical properties are not ideal for these applications. We describe the synthesis and characterization of NTAdeCage, the first member in a new class of Zn2+ photocages that utilizes a light-driven decarboxylation reaction in the metal ion release mechanism. NTAdeCage binds Zn2+ with sub-pM affinity using a modified nitrilotriacetate chelator and exhibits an almost 6 order of magnitude decrease in metal binding affinity upon uncaging. In contrast to other metal ion photocages, NTAdeCage and the corresponding Zn2+ complex undergo efficient photolysis with quantum yields approaching 30 %. The ability of NTAdeCage to mediate the uptake of 65Zn2+ by Xenopus laevis oocytes expressing hZIP4 demonstrates the viability of this photocaging strategy to execute biological assays. Light-driven metal release: A photodecarboxylation reaction has been exploited to design a photocaged complex for Zn2+ with superior properties compared to other caged metal complexes. The photocage has been used to control the uptake of Zn2+ in frog oocytes expressing a human zinc transport protein.
Expanding the repertoire of nitrilases with broad substrate specificity and high substrate tolerance for biocatalytic applications
Rayavarapu, Pratima,Shah, Shikha,Sunder, Avinash Vellore,Wangikar, Pramod P.
, p. 289 - 296 (2020/05/18)
Enzymatic conversion of nitriles to carboxylic acids by nitrilases has gained significance in the green synthesis of several pharmaceutical precursors and fine chemicals. Although nitrilases from several sources have been characterized, there exists a scope for identifying broad spectrum nitrilases exhibiting higher substrate tolerance and better thermostability to develop industrially relevant biocatalytic processes. Through genome mining, we have identified nine novel nitrilase sequences from bacteria and evaluated their activity on a broad spectrum of 23 industrially relevant nitrile substrates. Nitrilases from Zobellia galactanivorans, Achromobacter insolitus and Cupriavidus necator were highly active on varying classes of nitriles and applied as whole cell biocatalysts in lab scale processes. Z. galactanivorans nitrilase could convert 4-cyanopyridine to achieve yields of 1.79 M isonicotinic acid within 3 h via fed-batch substrate addition. The nitrilase from A. insolitus could hydrolyze 630 mM iminodiacetonitrile at a fast rate, effecting 86 % conversion to iminodiacetic acid within 1 h. The arylaliphatic nitrilase from C. necator catalysed enantioselective hydrolysis of 740 mM mandelonitrile to (R)-mandelic acid in 4 h. Significantly high product yields suggest that these enzymes would be promising additions to the suite of nitrilases for upscale biocatalytic application.
A METHOD OF IMINODIACETIC ACID
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Paragraph 0027; 0042-0044, (2018/06/29)
According to the present invention, a method for producing iminodiacetic acid comprises the following steps: (S1) hydrolyzing an aqueous solution of iminodiacetonitrile and calcium hydroxide; (S2) neutralizing the aqueous solution obtained in the step (S1) with hydrochloric acid; (S3) adding alcohol to the aqueous solution obtained in the step (S2) to produce an iminodiacetic acid precipitate; and (S4) filtering the precipitate produced in the step (S3) to obtain iminodiacetic acid. According to the present invention, it is possible to produce iminodiacetic acid at high purity and high yield.COPYRIGHT KIPO 2018
Synthesis of Deuterated or Tritiated Glycine and Its Methyl Ester
Shevchenko,Andreeva,Nagaev, I. Yu.,Myasoedov
, p. 266 - 267 (2019/01/03)
Abstract: Heating glycine (Gly) and methyl glycinate (GlyOCH3) supported on 5% Pd/C or 5% Pt/C in a deuterium or tritium gas atmosphere gave the isotope-labeled products. The experiments were carried out at 180°C for 10 min. The deuterium atom inclusion under these conditions averaged up to 1.8 atoms per molecule for Gly and up to 1.0 atom per molecule for GlyOCH3. The reaction with tritium gas gave labeled products with a specific radioactivity of 27–31 Ci/mmol for Gly and 18 Ci/mmol for GlyOCH3.
MANUFACTURING METHOD OF AMINOCARBOXYLIC ACID SALT
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Paragraph 0076, (2017/06/15)
PROBLEM TO BE SOLVED: To provide a manufacturing method of aminocarboxylic acid salt capable of suppressing and inhibiting generation of fastening of a coloring component in a reaction liquid containing the aminocarboxylic acid salt manufactured by oxidation dehydrogenation of amino alcohol in the presence of a copper-containing catalyst or capable of suppressing and inhibiting production of precipitate during manufacturing the aminocarboxylic acid from aminocarboxylic acid salt. SOLUTION: There is provided a manufacturing method for aminocarboxylic acid salt including oxidation dehydrogenation of amino alcohol in the presence of a copper-containing catalyst to obtain a reaction product and removing the copper-containing catalyst from the reaction product to obtain a reaction liquid containing aminocarboxylic acid salt having limitation of the total content (in terms of metals) of silicon (Si), aluminum (Al) and iron (Fe) to 100 mass.ppm or less. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
Iminodiacetic acid preparation method
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Paragraph 0029-0030, (2017/06/27)
A method for preparing iminodiacetic acid is characterized by comprising the following steps: (A), hydrolyzing iminodiacetonitrile into iminodiacetic acid disodium salt solution by virtue of sodium hydroxide; (B) adding ammonium sulfate or ammonium bisulfate into the hydrolysate to reach a certain pH value, neutralizing excessive sodium hydroxide and part of iminodiacetic acid disodium salt, and simultaneously recycling the produced ammonia so as to prepare ammonia water or liquid ammonia; and (C), adding sulfuric acid to regulate the pH value, cooling for crystallizing, separating so as to obtain iminodiacetic acid, and concentrating the filtrate to separate sodium sulfate to be used in the reaction in the next batch. The method for preparing iminodiacetic acid according to the claim 1 is characterized in that the pH value in the step (B) is 8-10. 3. The method for preparing iminodiacetic acid according to the claim 2 is characterized in that the pH value in the step (B) is 9.0-9.5. The method for preparing iminodiacetic acid according to any one of the claims 1-3 is characterized in that the pH value in the step (C) is 2.0-2.5.
