1135-40-6

Basic information

• Product Name: N-Cyclohexyl-3-aminopropanesulfonic acid
• Synonyms: CAPS 3-(Cyclohexylamino)-1-propanesulfonic acid;CAPS, Molecular Biology Grade 3-(Cyclohexylamino)-1-propanesulfonic acid, Molecular Biology Grade;CAPS, ULTROL Grade;3-cyclohexylaminopropane-1-sulphonic acid;CAPS, 99% (3-CYCLOHEXYLAMINO-1-PROPANE-S ULFONIC ACID);CHOLESTERYL PALMITATE 98+%;3-(CYCLOHEXYLAMINO)-PROPANE SULFONIC ACID (CAPS);CAPS, MOLECULAR BIOLOGY GRADE
• CAS NO: 1135-40-6
• Molecular Formula: C₉H₁₉NO₃S
• Molecular Weight: 221.32
• EINECS: 214-492-1
• Product Categories: Pharmaceutical Intermediates;buffer
• Mol File: 1135-40-6.mol

Chemical Properties

• Melting Point: >300 °C(lit.)
• Flash Point: >110℃
• Appearance: White/Powder/Solid
• Density: 1.1809 (rough estimate)
• Vapor Pressure: 0Pa at 25℃
• Refractive Index: 1.5250 (estimate)
• Storage Temp.: Store at RT.
• Solubility: H2O: 0.5 M at 20 °C, clear
• PKA: 10.4(at 25℃)
• Water Solubility: 9 g/100 mL (20 ºC)
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 14,1767
• BRN: 2835588
• CAS DataBase Reference: N-Cyclohexyl-3-aminopropanesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cyclohexyl-3-aminopropanesulfonic acid(1135-40-6)
• EPA Substance Registry System: N-Cyclohexyl-3-aminopropanesulfonic acid(1135-40-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/38-36/37/38-22-20/21/22-40/22
• Safety Statements: 26-36/37/39-37/39-24/25-22-23-36
• WGK Germany: 3
• RTECS: TZ6395000
• F: 34
• TSCA: Yes
• Hazardous Substances Data: 1135-40-6(Hazardous Substances Data)

Usage

Uses

Used in Biological Buffers:
N-Cyclohexyl-3-aminopropanesulfonic acid is used as a biological buffer for maintaining a stable pH environment in various biochemical processes and experiments.
Used in Western and Immunoblotting Experiments:
CAPS is used as a buffer salt to formulate CAPS buffer, which is widely utilized in Western and immunoblotting experiments. The high pH of this buffer makes it suitable for the transfer of proteins with a pI > 8.5.
Used in Protein Sequencing and Identification:
N-Cyclohexyl-3-aminopropanesulfonic acid is used as a buffer in protein sequencing and identification processes, providing a stable pH environment that is crucial for accurate results.
Used in Electrotransfer of Proteins:
CAPS buffer is employed in the electrotransfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718, sc-3724), facilitating the efficient transfer of proteins during these procedures.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C9H19NO3S/c11-14(12,13)8-4-7-10-9-5-2-1-3-6-9/h9-10H,1-8H2,(H,11,12,13)

Synthetic route

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + 2-(4-chlorophenyl)-3-methyl-(2SR)-butanoyl chloride (51631-50-6) + 3-Phenoxybenzaldehyde (39515-51-0) → FENVALERATE (51630-58-1)

Conditions	Yield
In n-heptane; water
In n-heptane; water

permethric acid chloride (52314-67-7) + 3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + 3-Phenoxybenzaldehyde (39515-51-0) → cypermethrine (52315-07-8)

Conditions	Yield
With sodium carbonate In n-heptane; water

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + tetra-n-butylphosphonium hydroxide (14518-69-5) → [TBP][CAPS]

Conditions	Yield
In water at 20℃;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + tetramethyl ammoniumhydroxide (75-59-2) → C9H18NO3S(1-)*C4H12N(1+)

Conditions	Yield
In water at 20℃; for 12h;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + tetraethylammonium hydroxide (77-98-5) → C9H18NO3S(1-)*C8H20N(1+)

Conditions	Yield
In water at 20℃; for 12h;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + tetra(n-butyl)ammonium hydroxide (2052-49-5) → 3-Cyclohexylamino-propane-1-sulfonatetetrabutyl-ammonium; (113599-05-6)

Conditions	Yield
In water at 20℃; for 12h;

N,N-dimethyl-cyclohexanamine (98-94-2) + 3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + Hexamethylene diisocyanate (822-06-0) → C17H31N3O5S*C8H17N

Conditions	Yield
at 80℃; for 3h;

hexamethylenediisocyanate uretdione (23501-81-7) + N,N-dimethyl-cyclohexanamine (98-94-2) + 3-(cyclohexylamino)propanesulfonic acid (1135-40-6) → C25H43N5O7S*C8H17N

Conditions	Yield
Heating;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + TPO chloride → C32H39NO5PS(1-)*K(1+)

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + (3,5-bis(chloromethyl)-2,4,6-trimethylphenyl)(diphenylphosphoryl)methanone → C42H57N2O8PS2(2-)*2K(1+)

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;

Downstream Products

• 51630-58-1 FENVALERATE 
• 52315-07-8 cypermethrine 
• 113599-05-6 3-Cyclohexylamino-propane-1-sulfonatetetrabutyl-ammonium; 

Relevant articles and documents

Isolation of nucleic acids

A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials possess a neutral or negative charge to release the nucleic acids. The nucleic acids can be removed under mildly alkaline conditions to the maintain integrity of the nucleic acids and to allow retrieval of the nucleic acids in reagents that are immediately compatible with either storage or analytical testing.

Zwitterionic compounds and their n-halo derivatives for use in the treatment of clinical conditions

Zwitterionic compounds selected from: taurine (2-aminoethanesulphonic acid), 2(N-morpholino)ethanesulphonic acid (MES), N-(2-acetamido)iminodiacetic acid (ADA), piperazine-N,N'bis(2-ethanesulphonic acid (PIPES), N-(2-acetamido)-2-aminoethanesulphonic acid (ACES), N,N-bis(2-hydroxyethyl)-2-aminoethanesulphonic acid (BES), 3-(N-morpholino)propanesulphonic (MOPS), N-N[tris(hydroxymethyl)-methyl]-2-aminoethanesulphonic acid (TES), N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid (HEPES), N-2-hydroxyethylpiperazine-N'3-propanesulphonic acid (H)EPPS), 2-(cyclohexylamino)ethanesulphonic acid (CHES) or 3-(cyclohexylamino)propanesulphonic acid (CAPS), and their N-halo derivatives can be used separately or in combination in the treatment of related clinical conditions by stimulating myeloperoxidase activity, which in turn stimulates hypochlorous acid production in vivo, which leads inter alia to enhanced leukotriene inactivation.

Use of zwitterionic compounds and their N-halo derivatives

Zwitterionic compounds selected from:, taurine (2-aminoethanesulphonic acid), 2(N-morpholino)ethanesulphonic acid (MES), N-(2-acetamido) iminodiacetic acid (ADA), piperazine-N,N?bis(2-ethanesulphonic acid (PIPES), N-(2-acetamido)-2-aminoethanesulphonic acid (ACES), N,N-bis(2-hydroxyethyl)-2-aminoethanesulphonic acid (BES), 3-(N-morpholino)propanesulphonic (MOPS), N-N[tris(hydroxymethyl)-methyl]-2-aminoethanesulphonic acid (TES), N-2-hydroxyethylpiperazine-N?-2-ethanesulphonic acid (HEPES), N-2-hydroxyethylpiperazine-N?3-propanesulphonic acid ((H)EPPS), 2-(cyclohexylamino) ethanesulphonic acid (CHES) or 3-(cyclohexylamino) propanesulphonic acid (CAPS), and their N-halo derivatives can be used separately or in combination in the treatment of related clinical conditions by stimulating myeloperoxidase activity, which in turn stimulates hypochlorous acid production in vivo, which leads inter aliato enhanced leukotriene inactivation.

Amino-phosphonic-sulfonic acids

This invention relates to compounds characterized by the presence of N-methyl, or substituted methyl, phosphonic acid and N-propylenesulfonic acid groups. These compounds contain at least one or more of each group and are bonded to the same or different amino groups. They are derived by reacting an amine with both propane sultone and with a carbonyl compound, such as formaldehyde, and phosphorous acid or its equivalent. They have a wide variety of uses, for example as scale and corrosion inhibitors, chelating agents, etc.