114331-06-5 Usage
Uses
Used in Enzyme Activity Assays:
H-LYS(Z)-OBZL HCL is used as a substrate in enzyme activity assays for the measurement of cathepsin K and L activities. Its cleavage by these enzymes can be quantified using fluorescence or absorbance measurements, providing a reliable method for assessing enzyme activity levels.
Used in Drug Discovery and Development Research:
In the field of drug discovery and development, H-LYS(Z)-OBZL HCL is used as a research tool to understand the mechanisms of lysosomal protease activity. It aids in the screening of potential therapeutic compounds that target cathepsin K and L enzymes, contributing to the advancement of treatments for various diseases.
Used in the Study of Lysosomal Storage Diseases and Related Disorders:
H-LYS(Z)-OBZL HCL is utilized in the study of lysosomal storage diseases and related disorders to investigate the role of cathepsin K and L enzymes in these conditions. By monitoring the activity of these enzymes, researchers can gain insights into the pathophysiology of these diseases and identify potential therapeutic targets.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, H-LYS(Z)-OBZL HCL is used as a research tool for the development of drugs targeting cathepsin K and L enzymes. Its ability to be cleaved by these enzymes and the quantification of this cleavage allows for the assessment of drug efficacy and the optimization of drug candidates.
Used in Biomedical Research:
H-LYS(Z)-OBZL HCL is used in biomedical research as a substrate to study the function and regulation of cathepsin K and L enzymes. This knowledge can contribute to a better understanding of various biological processes and the development of targeted therapies for diseases associated with these enzymes.
Check Digit Verification of cas no
The CAS Registry Mumber 114331-06-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,3,3 and 1 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 114331-06:
(8*1)+(7*1)+(6*4)+(5*3)+(4*3)+(3*1)+(2*0)+(1*6)=75
75 % 10 = 5
So 114331-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2O4.ClH/c22-18(20(24)26-14-16-8-3-1-4-9-16)12-7-13-19(23)21(25)27-15-17-10-5-2-6-11-17;/h1-6,8-11,18-19H,7,12-15,22-23H2;1H/t18-,19+;
114331-06-5Relevant articles and documents
Synthesis and Spectroscopic Properties of Fluorinated Coumarin Lysine Derivatives
Shukla, Lakshmi,Moodie, Lindon W. K.,Kindahl, Tomas,Hedberg, Christian
supporting information, p. 4792 - 4799 (2018/04/25)
The site-selective incorporation of fluorescent amino acids into proteins has emerged as a valuable alternative to expressible protein reporters. For successful application, a robust and scalable, yet flexible, route to non-natural amino acids is required. This work describes an improved synthesis of coumarin-conjugated lysine derivatives where fluorinated variants are accessed. These analogues can be utilized at low pH and should find application probing biological processes that operate under acidic conditions.
