116064-77-8Relevant articles and documents
Semisynthesis of miltirone, 1,2-dehydromiltirone, saligerone from carnosic acid and cytotoxities of their derivatives
Li, Cheng-Ji,Xia, Fan,Zhang, Wen,Wang, Kou,Xu, Gang,Qin, Hong-Bo
supporting information, p. 2607 - 2609 (2018/05/30)
Miltirone, 1,2-dehydromiltirone, saligerone have been synthesized form carnosic acid. Among them, one step transformation of carnosic acid into miltirone was realized when decarboxylation/aromatization was promoted by Lewis acid. Moreover, 4 derivatives e
Preparation method of miltirone and dehydromiltirone
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Paragraph 0047; 0052; 0053; 0054, (2018/10/19)
The invention provides a preparation method of miltirone and dehydromiltirone, which comprises the following steps of: adding a lewis acid into the carnosic acid, and performing one-step reaction of dearomatization to obtain the miltirone; taking the miltirone as a raw material, heating in an organic solvent containing the protonic acid, and carrying out a step of proton transfer and o-phenol oxidation to obtain the dihydro-miltirone. The preparation method adopts the method of the short step of taking the natural product carnosic acid as the raw material, one-step synthesizing the miltirone ,and further synthesizes the dihydro-miltirone., so that the solvent utilization and the discharge of the pollutants are reduced. And the carnosic acid can be obtained in a large amount, so the methodhas high efficiency and is superior to the prior art.
Use of conjugated dienones in cyclialkylations: Total syntheses of arucadiol, 1,2-didehydromiltirone, (±)-hinokione, (±)-nimbidiol, sageone, and miltirone
Majetich, George,Liu, Shuang,Fang, Jing,Siesel, David,Zhang, Yong
, p. 6928 - 6951 (2007/10/03)
Functionalized hydrophenanthrenes can be prepared using a cyclialkylation-based strategy. These annulations are highly dependent on the directing effects of the arene substitutents and on conformational considerations. The utility of this methodology was featured in the syntheses of six diterpenoids.
Structure Elucidation and Total Synthesis of New Tanshinones Isolated from Salvia miltiorrhiza Bunge (Danshen)
Chang, Hson Mou,Cheng, Kwok Ping,Choang, Tai Francis,Chow, Hak Fun,Chui, Kuk Ying,et al.
, p. 3537 - 3543 (2007/10/02)
Totally 11 new compounds have been isolated from the dried root of Salvia miltiorrhiza Bunge "Danshen" and their structures were elucidated by means of spectrometric methods.The total syntheses of two new compounds, namely, 1,2-didehydromiltirone and 4-methylenemiltirone, are also reported.