118418-23-8

Basic information

• Product Name: [1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL
• Synonyms: [1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL
• CAS NO: 118418-23-8
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.22646
• Mol File: 118418-23-8.mol

Chemical Properties

• Boiling Point: 352.6°C at 760 mmHg
• Flash Point: 167°C
• Appearance: /
• Density: 1.226g/cm³
• Vapor Pressure: 1.41E-05mmHg at 25°C
• Refractive Index: 1.548
• PKA: 14.09±0.20(Predicted)
• CAS DataBase Reference: [1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL(118418-23-8)
• EPA Substance Registry System: [1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL(118418-23-8)

Safety Data

• Hazardous Substances Data: 118418-23-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL is used as a reagent for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Organic Synthesis:
[1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL is used as an intermediate in the preparation of other organic compounds. Its versatility in chemical reactions makes it a valuable building block for the synthesis of complex molecules.
Used in Medicinal Chemistry:
[1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL is used as a structural component in the design and development of new drugs. Its potential biological activities and compatibility with various molecular targets make it a promising candidate for creating novel therapeutic agents.
Used in Drug Development:
[1,3]DIOXOLAN-2-YL-(4-METHOXY-PHENYL)-METHANOL is used in the research and development of new drugs. Its structural properties and potential interactions with biological systems make it a valuable tool for exploring new therapeutic approaches and advancing the field of medicinal chemistry.

InChI:InChI=1/C11H14O4/c1-13-9-4-2-8(3-5-9)10(12)11-14-6-7-15-11/h2-5,10-12H,6-7H2,1H3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 19798-66-4 2-(Phenylthio)-1,3-dioxolane 
• 646-06-0 1,3-DIOXOLANE 

Relevant articles and documents

Radical α-C-H hydroxyalkylation of ethers and acetal

(Chemical Equation Presented) Ethers and an acetal were found to undergo direct intermolecular addition to aldehydes under the Et3B/air conditions. This study presents a very unique and simple means for the radical α-C-H hydroxyalkylation of oxygen-containing compounds.

(Dialkoxymethyl)lithiums: Generation, Stability, and Synthetic Transformations

(Dialkoxymethyl)lithium reagents, (RO)2CHLi, can be generated simply and efficiently and employed as synthetically useful one-carbon nucleophiles.Reductive lithiation of phenylthio-substituted precursors, (RO)2CHSPh, at -95 deg C or transmetalation of tri-n-butylstannyl compounds, (RO)2CHSn(n-Bu)3, at -110 to -111 deg C afforded the acyclic species (MeO)2CHLi (4) and (EtO)2CHLi (5).The cyclic reagents, 2-lithio-1,3-dioxolane (6) and 2-lithio-1,3-dioxane (7), were similarly prepared at -78 deg C by reductive lithiation or transmetalation.Reactions of(dialkoxymethyl)lithiums with electrophiles, including aldehydes, ketones, 2-cyclohexen-1-one (1,2- or 1,4-addition as desired), dimethyl sulfate, primary alkyl bromides, epoxides, oxetane, and n-Bu3SnCl, afforded structurally diverse, functionalized acetals.In these experiments, which emphasized transformations of lithiodioxane 7, yields of products generally exceeded 90percent.The thermal stability of each reagent was investigated at several temperatures.The acyclic compounds 4 and 5 decompose rapidly even at -95 deg C, whereas lithiodioxolane 6 and dioxane derivative 7 are relatively stable at -78 and -45 deg C, respectively.These striking differences in solution lifetimes can be rationalized in terms of alternative decomposition pathways and steric and stereoelectronic factors.The primary products of thermal decomposition of 7 can be ascribed to formation of a reactive carbene or carbenoid via α-elimination.Equilibration experiments established that (dialkoxymethyl)lithium 7 is more stable thermodynamically than the α-monoalkoxy species lithium, in accord with previous ab initio calculations.