118419-93-5

Basic information

• Product Name: 3-(2-CHLORO-3-PYRIDYL)ACRYLIC ACID
• Synonyms: 3-(2-CHLORO-3-PYRIDYL)ACRYLIC ACID
• CAS NO: 118419-93-5
• Molecular Formula: C₈H₆ClNO₂
• Molecular Weight: 183.59174
• Mol File: 118419-93-5.mol

Chemical Properties

• Melting Point: 195-199 °C
• Boiling Point: 347.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.409±0.06 g/cm3(Predicted)
• PKA: 3.28±0.10(Predicted)
• CAS DataBase Reference: 3-(2-CHLORO-3-PYRIDYL)ACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-CHLORO-3-PYRIDYL)ACRYLIC ACID(118419-93-5)
• EPA Substance Registry System: 3-(2-CHLORO-3-PYRIDYL)ACRYLIC ACID(118419-93-5)

Safety Data

• Hazardous Substances Data: 118419-93-5(Hazardous Substances Data)

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 148247-84-1 3-(2-chloro-3-pyridinyl)-(E)-2-propenoic acid ethyl ester 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 494841-74-6 (4R,5S)-3-[(E)-3-(2-Chloro-pyridin-3-yl)-acryloyl]-4,5-diphenyl-oxazolidin-2-one 
• 494841-73-5 (R)-3-[(E)-3-(2-Chloro-pyridin-3-yl)-acryloyl]-5,5-dimethyl-4-phenyl-oxazolidin-2-one 
• 494841-71-3 (4S,5R)-3-[(E)-3-(2-Chloro-pyridin-3-yl)-acryloyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 494841-70-2 (S)-3-[(E)-3-(2-Chloro-pyridin-3-yl)-acryloyl]-4-phenyl-oxazolidin-2-one 
• 118420-32-9 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(2-chloro-pyridin-3-yl)-acrylamide 

Relevant articles and documents

Asymmetric synthesis of a selective endothelin a receptor antagonist

An asymmetric synthesis of a selective endothelin A receptor antagonist 1b is described. Asymmetric conjugate addition of aryllithium derived from 18 to the chiral oxazoline 17 followed by hydrolysis afforded 15 in 96% ee via purification as (S)-(-)-1-phe

Tetrazole amide derivatives of heterocyclic alkenyl acid and their use as antiallergic substances

Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula STR1 in which Y=NH, O or S when m=1; Y=N when m=2; m=1 or 2; l=0 or 4; R=H, C1-4 alkyl, Cl, Br, CF3, CH2 OCOCH3, or OCH2 -Ph; R1 =H, alkaline metal or alkaline earth metal, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Such derivatives possess high antiallergic activity.

Tetrazole amide derivatives of heterocyclic alkenyl acids and their use as antiallergic substances

Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula (I): in which, Y = NH, O or S when m = 1;, Y = N when m = 2;, m = 1 or 2;, l = 0 or 4;, R = H, C1 4 alkyl, Cl, Br, CF3, CH2OCOCH3, or OCH2-Ph;, R1 = H, alkaline metal or alkaline earth metal;, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Said derivatives possess high antiallergic activity.

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.