1191997-59-7Relevant articles and documents
Deuterated pyrrolidone derivative Pharmaceutical compositions and uses thereof
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Paragraph 0065-0066; 0068, (2021/10/27)
The invention relates to a deuterated pyrrolidone derivative and a preparation method thereof, and also relates to application of the deuterated pyrrolidone derivative and a pharmaceutical composition thereof in treatment and prevention of metabolic disorder related diseases, and belongs to the field of medicines.
Copper-catalyzed three-component reactions of phenols, acyl chlorides and Wittig reagents for the synthesis of β-aryloxyl acrylates
Zhang, Yi,Liu, Yunyun,Wan, Jie-Ping
supporting information, p. 1567 - 1569 (2015/03/18)
The synthesis of aryloxyl acrylates has been achieved through a new three-component synthetic method involving the assembly of phenols, acyl chlorides and Wittig reagents in the presence of a copper catalyst using glucose as a green ligand. β-Aryloxyl acrylates have been prepared with high diversity and in good to excellent yields involving the cascade formation of a new CC bond and a C(sp2)-O bond.
Enantioselective synthesis of β-aryloxycarboxylic esters via asymmetric hydrogenation of β-aryloxy-α,β-unsaturated esters
Stewart, Gavin W.,Yamagata, Adam D. Gammack,Gibson, Andrew W.,Keen, Stephen P.,Scott, Jeremy P.,Shevlin, Michael
supporting information, p. 5440 - 5443,4 (2012/12/12)
A novel synthesis of β-aryloxycarboxylic esters via asymmetric hydrogenation of the corresponding β-aryloxy-α,β-unsaturated esters has been demonstrated. Bis(norbornadiene)rhodium(I) tetrafluoroborate (1 mol %) and Walphos W008-1 were used to generate the
PYRROLIDINONE GLUCOKINASE ACTIVATORS
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Page/Page column 58-59, (2009/10/30)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.