119905-05-4

Basic information

• Product Name: Delequamine
• Synonyms: Delequamine;(8aR)-3-Methoxy-12-(methylsulfonyl)-5,8,8aα,9,10,11,12,12aα,13,13aα-decahydro-6H-isoquino[2,1-g][1,6]naphthyridine;(8aR)-5,8,8aα,9,10,11,12,12aα,13,13aα-Decahydro-12-(methylsulfonyl)-3-methoxy-6H-isoquino[2,1-g][1,6]naphthyridine;RS-15385-197;RS-42206;Delequamine [inn]
• CAS NO: 119905-05-4
• Molecular Formula: C18H26N2O3S
• Molecular Weight: 350.48
• Mol File: 119905-05-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Delequamine(CAS DataBase Reference)
• NIST Chemistry Reference: Delequamine(119905-05-4)
• EPA Substance Registry System: Delequamine(119905-05-4)

Safety Data

• Hazardous Substances Data: 119905-05-4(Hazardous Substances Data)

Usage

Uses

Impotence therapy adjunct.

Upstream product

• 129214-09-1 (8aR,12aS,13aR)-(+)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-methylsulfonyl-6H-isoquino<2,1-g><1,6>naphthyridine 
• 119814-02-7 (8AR,12AS,13AS)-3-methoxy-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine 
• 124-63-0 methanesulfonyl chloride 
• 14446-29-8 6-Methoxy-3,4-dihydroisoquinoline 
• 60511-47-9 2-methylnicotinic acid diethylamide 
• 119813-94-4 5,8,13,13a-tetrahydro-3-methoxy-8-oxo-6H-isoquino<2,1-g><1,6>naphthyridine 
• 119813-98-8 8aα,12aα,13aα-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-8-oxo-6H-isoquino<2,1-g><1,6>naphthyridine 
• 119814-00-5 (8aS,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-<(R)-(1-phenylethyl)carbamoyl>-8-oxo-6H-isoquino<2,1-g><1,6>naphthyridine 
• 10412-98-3 5-oxohexanenitrile 
• 10590-54-2 trimethyl-(2-acetyl-4-cyanobutyl)ammonium iodide 
• 119814-02-7 (8aR,12aS,13aR)-(+)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-6H-isoquino<2,1-g><1,6>naphthyridine 
• 129158-07-2 (+/-)-3-<9-methoxy-2-oxo-1,3,4,6,7,11bα-hexahydro-2H-benzoquinolizinyl(3α)>propionitrile 
• 129214-04-6 (3R,11bS)-(+)-3-(9-methoxy-2-oxo-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizinyl)propionitrile 

Relevant articles and documents

Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1,6] naphthyridines at α-adrenoceptors

Analogues of the potent α2-adrenoceptor antagonist (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12- (methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine (1b) were prepared and evaluated for α1- and α2-

PREPARATION OF ENANTIOMERICALLY PURE DECAHYDRO-6H-ISOQUINONAPHTHYRIDINES UTILIZING THE OPENSHAW-WHITTAKER HEXAHYDROBENZOQUINOLIZINONE RESOLUTION

The (8aR,12aS,13aS)-decahydro-6H-isoquinonaphthyridine sulfonamides 1a,b were prepared from (+)-(3R,11bS)-3-cyanoethylhexahydrobenzoquinolizinones 3a,b.These key intermediates were obtained by resolution of (+/-)-3a,b with (+)-camphorsulfonic acid in ethyl acetate according to the conditions used in the Openshaw-Whittaker synthesis of (-)-emetine.

Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers

Compounds of the formula (1): STR1 in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy, and R is lower alkyl, optionally substituted phenyl, --(CH2)m OR1 or --NR1 R2, wherein m is an integer of 1 to 6 and R1 and R2 are independently hydrogen or lower alkyl, or --NR1 R2 taken together is a heterocycle of the formula: STR2 wherein A is --CH2 --, --NR1 -- or oxygen; or a pharmaceutically acceptable salt thereof, are useful as selective α2 -blockers.