120113-87-3Relevant articles and documents
Copper-Catalyzed Tandem Conjugate Addition-Electrophilic Trapping: Ketones, Esters, and Nitriles as Terminal Electrophiles
Agapiou, Kyriacos,Cauble, David F.,Krische, Michael J.
, p. 4528 - 4529 (2007/10/03)
Exposure of enone substrates 1a?18a, which possess appendant ketone, ester, and nitrile moieties, to Et2Zn in the presence of catalytic Cu(OTf)2/P(OEt)3 provides the cyclized products in good to excellent yields and diastereoselectivities. These results represent the first use of ketones, esters, and nitriles as terminal electrophiles in Cu-catalyzed conjugate addition?electrophilic trapping. Copyright
New synthesis of a pyrroloquinoline skeleton, the martinelline core, using a tandem Michael-aldol strategy
Hara, Osamu,Sugimoto, Kazuhiko,Makino, Kazuishi,Hamada, Yasumasa
, p. 1625 - 1627 (2007/10/03)
The pyrroloquinoline moiety of Martinelline, a naturally occurring bradykinin receptor antagonist, has been synthesized from 1,2-dihydroquinoline which was prepared by using a tandem Michael-aldol reaction as a key step.
Cobalt-Mediated Intermolecular Radical Additions to Carbon-to-Carbon Double Bonds leading to New Functionalised Alkenes
Bhandal, Harcharan,Howell, Amy R.,Patel, Vinod F.,Pattenden, Gerald
, p. 2709 - 2714 (2007/10/02)
Alkyl radicals generated by photolytic homolysis of cobalt salophen reagents, e.g. (6) and (15), are shown to add to activated carbon-to-carbon double bonds, i.e. ethyl acrylate, methyl vinyl ketone, acrylonitrile, and styrene, producing preparatively useful yields of new alkene products, viz. (9), (10), (12) and (14) , and (16) .The reactions proceed via radical (Michael) additions, followed by 'dehydrocobaltation' from the presumed organocobalt intermediates (2) (Scheme 4).By use of this chemistry, in combination with the Schrauzer 'hydrocobaltation' reaction of alkenes, a new method for the cross-coupling reactions between two alkenes, leading to new functionalised alkenes, e.g. (24), (25), (26), (27), (28), and (29), is developed .
Hydrocobaltation-Dehydrocobaltation Reactions in Synthesis: A New Approach to the Controlled Cross-Coupling between sp2 Carbon Centres leading to Functionalised Alkenes
Bhandal, Harcharan,Pattenden, Gerald
, p. 1110 - 1112 (2007/10/02)
Cross-coupling reactions between two alkenes, leading to new functionalised alkenes, can be brought about via 'hydrocobaltation' of one of the alkenes followed by irradiation of the resulting organocobalt reagent in the presence of the second alkene subst
