Welcome to LookChem.com Sign In|Join Free

Cas Database

1203-24-3

1203-24-3

Identification

Synonyms:Maleimide,N-(o-chlorophenyl)- (6CI,7CI,8CI);(o-Chlorophenyl)maleimide;Chlorophenylmaleimide;N-(2-Chlorophenyl)maleimide;N-(o-Chlorophenyl)maleimide;

Post Buying Request Now

Safety information and MSDS view more

  • Pictogram(s):Xi,Xn

  • Hazard Codes:Xi,Xn

  • Signal Word:Danger

  • Hazard Statement:H302 Harmful if swallowedH315 Causes skin irritation H318 Causes serious eye damage H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:1-(2-Chlorophenyl)-1H-pyrrole-2,5-dione
  • Packaging:500mg
  • Price:$ 200
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:1-(2-Chlorophenyl)-1H-pyrrole-2,5-dione
  • Packaging:50mg
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:N-(2-CHLOROPHENYL)-MALEIMIDE Aldrich
  • Packaging:250mg
  • Price:$ 144
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:1-(2-Chlorophenyl)-1H-pyrrole-2,5-dione
  • Packaging:500mg
  • Price:$ 95
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-(O-Chlorophenyl)maleimide
  • Packaging:100 mg
  • Price:$ 100
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-(O-Chlorophenyl)maleimide
  • Packaging:50 mg
  • Price:$ 65
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-(O-Chlorophenyl)maleimide
  • Packaging:250 mg
  • Price:$ 150
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-(O-Chlorophenyl)maleimide
  • Packaging:500 mg
  • Price:$ 250
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-(O-Chlorophenyl)maleimide
  • Packaging:1 g
  • Price:$ 450
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1-(2-CHLORO-PHENYL)-PYRROLE-2,5-DIONE 95.00%
  • Packaging:5G
  • Price:$ 1016.4
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 11 Articles be found

Inter-Ring Torsions in N-Phenylmaleimide and Its o-Halo Derivatives: An Experimental and Computational Study

Miller, Christopher W.,Hoyle, Charles E.,Valente, Edward J.,Magers, David H.,Joensson, E. Sonny

, p. 6406 - 6412 (1999)

Structures of N-phenylmaleimide and its o-halophenyl derivatives have been determined in the solid state and show the angle between the phenyl and pyrolinyl ring planes to vary from 49.5° to 83.9° with increasing values for compounds with the larger ortho halophenyl substituents (H F ≤ Cl ≤ Br I). Experimental torsions and trends in the series are supported by semiempirical AM1 and ab initio SCF, DFT, and MP2 calculations. Calculations (AM1) on N-phenylmaleimide modeling the torsional deformation between the rings show that the barrier to planarity has a lower energy than that through a perpendicular conformation. In its o-halo derivatives, molecular planarity is not possible, and torsional deformation proceeds through the perpendicular conformation with diminishing, possibly vanishing, barriers with increasing halogen size. For chloro, bromo, and iodo derivatives, twisted ground-state molecular conformations reside in broad minima essentially centered around the perpendicular conformations. The unusually strong, longer wavelength electronic bands observed in the solution spectra of the series were modeled by Zindo/S CIS computations at the optimum AM1 molecular geometries. The observed lower energy (285-305 nm) band for the parent through the o-bromo derivative appears to arise from a {n(O,N); π (phenyl)} → π*(maleimide) transition. The next higher energy (250-285 nm) band appears to be essentially a phenyl π Ρ π* transition. In the o-iodo derivative, a phenyl π → * (C-I) transition appears to contribute to the longer wavelength band. Trends in the observed electronic spectra in acetonitrile within the series of compounds accord roughly with the results of the computations.

Catalyst and Additive-Free Diastereoselective 1,3-Dipolar Cycloaddition of Quinolinium Imides with Olefins, Maleimides, and Benzynes: Direct Access to Fused N,N′-Heterocycles with Promising Activity against a Drug-Resistant Malaria Parasite

Kumar, Rakesh,Chaudhary, Sandeep,Kumar, Rohit,Upadhyay, Pooja,Sahal, Dinkar,Sharma, Upendra

, p. 11552 - 11570 (2018/09/25)

A convenient and eco-friendly synthesis of various fused N-heterocyclic compounds through catalyst and additive-free 1,3 dipolar cycloadditions of quinolinium imides with olefins, maleimides, and benzynes in excellent yields and diastereoselectivities is reported. The thermally controlled diastereoselective [3 + 2] cycloaddition reaction between quinolinium imides and olefins provided cis-isomers at low temperature and trans-isomers at high temperature. A reaction between quinolinium imides with substituted maleimides gave four-ring-fused N-heterocyclic compounds in high yields as a single diastereomer. The aryne precursors also provided four-ring-fused N,N′-heterocyclic compounds in high yields. The in vitro antiplasmodial activity of selected molecules revealed that this class of molecules possesses potential for ongoing studies against malaria.

Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita

Eloh, Kodjo,Demurtas, Monica,Mura, Manuel Giacomo,Deplano, Alessandro,Onnis, Valentina,Sasanelli, Nicola,Maxia, Andrea,Caboni, Pierluigi

, p. 4876 - 4881 (2016/07/06)

Different maleimide derivatives were synthesized and assayed for their in vitro activity on the soil inhabiting, plant-parasitic nematode Meloidogyne incognita, also known as root-knot nematode. The compounds maleimide, N-ethylmaleimide, N-isopropylmaleimide, and N-isobutylmaleimide showed the strongest nematicidal activity on the second stage juveniles of the root-knot nematode with EC50/72h values of 2.6 ± 1.3, 5.1 ± 3.4, 16.2 ± 5.4, and 19.0 ± 9.0 mg/L, respectively. We also determined the nematicidal activity of copper sulfate, finding an EC50 value of 48.6 ± 29.8 mg/L. When maleimide at 1 mg/L was tested in combination with copper sulfate at 50 mg/L, we observed 100% mortality of the nematodes. We performed a GC-MS metabolomics analysis after treating nematodes with maleimide at 8 mg/L for 24 h. This analysis revealed altered fatty acids and diglyceride metabolites such as oleic acid, palmitic acid, and 1-monopalmitin. Our results suggest that maleimide may be used as a new interesting building block for developing new nematicides in combination with copper salts.

Process route upstream and downstream products

Process route

3-(2-chloro-phenylcarbamoyl)acrylic acid

3-(2-chloro-phenylcarbamoyl)acrylic acid

N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

Conditions
Conditions Yield
With sulfuric acid; In dimethyl sulfoxide; toluene; for 4h; Heating;
With sodium acetate; acetic anhydride; at 100 ℃; for 2h;
With sodium acetate; In acetic anhydride; for 1.5h; Reflux;
With sodium acetate; In acetic anhydride; at 120 ℃; for 0.5h; Microwave irradiation;
maleic anhydride
108-31-6

maleic anhydride

o-chloroaniline
95-51-2

o-chloroaniline

N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

Conditions
Conditions Yield
maleic anhydride; o-chloroaniline; In toluene; for 16h; Reflux;
With sodium acetate; acetic anhydride; at 100 ℃; for 0.5h;
30%
maleic anhydride; o-chloroaniline; In N,N-dimethyl-formamide; at 30 ℃; for 1h;
With acetic anhydride; In N,N-dimethyl-formamide; at 80 ℃; for 16h;
maleic anhydride; o-chloroaniline; In diethyl ether; at 20 ℃;
With sodium acetate; acetic anhydride; at 120 ℃;
With sulfuric acid; In acetic acid; at 60 ℃;
(2-chlorophenyl)maleamic acid
53616-16-3

(2-chlorophenyl)maleamic acid

N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

Conditions
Conditions Yield
With sulfuric acid; In dimethyl sulfoxide; toluene; Heating;
100%
With sodium acetate; acetic anhydride;
With sodium acetate; acetic anhydride; for 0.5h; Heating;
o-chloroaniline
95-51-2

o-chloroaniline

N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: diethyl ether / 20 °C
2: conc. H2SO4 / toluene; dimethylsulfoxide / 4 h / Heating
With sulfuric acid; In diethyl ether; dimethyl sulfoxide; toluene;
Multi-step reaction with 2 steps
1: 92 percent Chromat. / benzene / 0.5 h / Ambient temperature
2: 40 percent Chromat. / H2SO4 / Heating; overnight
With sulfuric acid; In benzene;
Multi-step reaction with 2 steps
1: dichloromethane / 1 h / 20 °C
2: acetic anhydride; sodium acetate / 2 h / 100 °C
With sodium acetate; acetic anhydride; In dichloromethane;
Multi-step reaction with 2 steps
1: diethyl ether / 1.5 h / 25 °C
2: sodium acetate / acetic anhydride / 1.5 h / Reflux
With sodium acetate; In diethyl ether; acetic anhydride;
Multi-step reaction with 2 steps
1: 0.5 h / 20 °C
2: sodium acetate / acetic anhydride / 0.5 h / 120 °C / Microwave irradiation
With sodium acetate; In acetic anhydride;
o-chloroaniline
95-51-2

o-chloroaniline

N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 100 percent / diethyl ether
2: 100 percent / H2SO4 / toluene; dimethylsulfoxide / Heating
With sulfuric acid; In diethyl ether; dimethyl sulfoxide; toluene; 1: Ring cleavage / 2: Cyclization;
methanol
67-56-1

methanol

(2-chlorophenyl)maleamic acid
53616-16-3

(2-chlorophenyl)maleamic acid

N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

(Z)-3-methoxycarbonyl-N-(o-chlorophenyl)propenamide
80167-52-8

(Z)-3-methoxycarbonyl-N-(o-chlorophenyl)propenamide

(E)-3-methoxycarbonyl-N-(o-chlorophenyl)propenamide
80167-60-8

(E)-3-methoxycarbonyl-N-(o-chlorophenyl)propenamide

Conditions
Conditions Yield
With sulfuric acid; Heating; overnight;
40 % Chromat.
With sulfuric acid; Title compound not separated from byproducts; Heating; overnight;
40 % Chromat.
N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

Conditions
Conditions Yield
Bernsteinsaeureanhydrid, entspr. Anilin, 2 Stufen;
Maleinsaeureanhydrid 1. o-Chloranilin 2. p-TosOH;
N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

Cyanothioacetamide
7357-70-2

Cyanothioacetamide

4-(2-Chloro-phenyl)-5-oxo-2-thioxo-1,2,4,5,6,6a-hexahydro-pyrrolo[3,2-b]pyrrole-3-carbonitrile

4-(2-Chloro-phenyl)-5-oxo-2-thioxo-1,2,4,5,6,6a-hexahydro-pyrrolo[3,2-b]pyrrole-3-carbonitrile

Conditions
Conditions Yield
With triethylamine; In ethanol; for 2h; Heating;
65%
N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

2-diazo-indan-1,3-dione
1807-49-4

2-diazo-indan-1,3-dione

2-methylphenyl aldehyde
529-20-4

2-methylphenyl aldehyde

5-(2-chlorophenyl)-3-(o-tolyl)-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetraone

5-(2-chlorophenyl)-3-(o-tolyl)-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetraone

Conditions
Conditions Yield
With dirhodium tetraacetate; In 1,2-dichloro-ethane; at 80 ℃; Molecular sieve; Inert atmosphere;
60.2%
N-(2-chlorophenyl)maleimide
1203-24-3

N-(2-chlorophenyl)maleimide

2-diazo-indan-1,3-dione
1807-49-4

2-diazo-indan-1,3-dione

m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

5-(2-chlorophenyl)-3-(m-tolyl)-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene] -1',3',4,6(3H,5H)-tetraone

5-(2-chlorophenyl)-3-(m-tolyl)-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene] -1',3',4,6(3H,5H)-tetraone

Conditions
Conditions Yield
With dirhodium tetraacetate; In 1,2-dichloro-ethane; at 80 ℃; Molecular sieve; Inert atmosphere;
57.1%

Global suppliers and manufacturers

Global( 21) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
  • PRIME MOLECULAR CO.,LIMITED
  • Business Type:Trading Company
  • Contact Tel:0852-0755-61104662
  • Emails:sales@prime-molecular.com
  • Main Products:1
  • Country:China (Mainland)
  • Yinghao Pharm Co.,Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-519-85390519
  • Emails:sales@haopharm.com
  • Main Products:1
  • Country:China (Mainland)
  • Debye Scientific
  • Business Type:Lab/Research institutions
  • Contact Tel:+85221376140
  • Emails:sales@debyesci.com
  • Main Products:1
  • Country:China (Mainland)
  • NovaChemistry
  • Business Type:Trading Company
  • Contact Tel:+44 (0)208 191 7890
  • Emails:info@novachemistry.com
  • Main Products:1
  • Country:United Kingdom
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1203-24-3
Post Buying Request Now
close
Remarks: The blank with*must be completed