1210-35-1

Basic information

• Product Name: Dibenzosuberone
• Synonyms: Dibenzosuberone10,11-Dihydro-5H-;10,11-dihydro-dibenzo [a, d] cyclohepten-5-one DBS;Amitriptyline Related Compound A (25 mg) (dibenzosuberone);10,11-Dihydrodibenzo[a,d]cycloheptanone;10,11-Dihydrodibenzo[a,d]cyclohepten-5-one;2,3:6,7-Dibenzosuberone;d)cyclohepten-5-one,10,11-dihydro-5h-dibenzo(;d]cyclohepten-5-one,10,11-dihydro-5h-dibenzo[
• CAS NO: 1210-35-1
• Molecular Formula: C₁₅H₁₂O
• Molecular Weight: 208.26
• EINECS: 214-912-3
• Product Categories: Pharmaceutical Intermediates;Functional Materials;Photopolymerization Initiators;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C15 to C38;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks;Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1210-35-1.mol

Chemical Properties

• Melting Point: 32-34 °C(lit.)
• Boiling Point: 148 °C0.3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow/Liquid or Low Melting Solid
• Density: 1.156 g/mL at 25 °C(lit.)
• Vapor Pressure: 6.35E-06mmHg at 25°C
• Refractive Index: n20/D 1.6332(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: 0.03g/l
• Water Solubility: insoluble
• BRN: 1454355
• CAS DataBase Reference: Dibenzosuberone(CAS DataBase Reference)
• NIST Chemistry Reference: Dibenzosuberone(1210-35-1)
• EPA Substance Registry System: Dibenzosuberone(1210-35-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• RTECS: HP1149700
• TSCA: Yes
• Hazardous Substances Data: 1210-35-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Dibenzosuberone is used as a key intermediate in the synthesis of antidepressant compounds for the treatment of mood disorders and mental health conditions. Its role in the production of medications like amitriptyline highlights its significance in developing effective treatments for depression and related conditions.
Used in Chemical Synthesis:
As a potential antidepressant compound, Dibenzosuberone is utilized in the chemical synthesis process to create various pharmaceutical products. Its unique properties and reactivity make it a valuable component in the development of new and improved medications to address mental health needs.

InChI:InChI=1/C15H12O/c16-15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)15/h1-8H,9-10H2

Upstream product

• 4890-85-1 o-phenethylbenzoic acid 
• 36795-27-4 diphenylethane-2-carboxylic acid chloride 
• 74764-62-8 1-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-piperidine 
• 15323-21-4 10,10’,11,11’-tetrahydro-5H,5’H-5,5’-bidibenzo[a,d][7]annulene 
• 67-56-1 methanol 
• 6141-55-5 5-diazo-10,11-dihydro-5H-dibenzo[a,d]cycloheptene 
• 109217-77-8 5-diazo-10,11-dihydro-5H-dibenzocycloheptene radical cation 
• 833-48-7 dibenzosuberane 
• 30090-45-0 5-hydrazinomethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol 
• 10354-00-4 5H-dibenzo[a,d]cyclohepten-5-ol 
• 3436-04-2 5-(3-bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene 
• 55090-32-9 5-hydroxy-5-phenyl-10,11-dihydrodibenzo[a,d]cycloheptene 
• 118797-91-4 C₁₅H₁₂O₂ 
• 101023-24-9 5-(3,3-dimethyl-2-oxo-2,3-dihydroindol-1-yl)-10,11-dihydrodibenzocyclohepten-1-yl 2-methylpropanoate 

Downstream Products

• 15323-25-8 10,11-dihydro-5-hydroxy-5-methyl-5H-dibenzocycloheptene 
• 55090-32-9 5-hydroxy-5-phenyl-10,11-dihydrodibenzo[a,d]cycloheptene 
• 24167-44-0 10-Brom-5-oxo-10,11-dihydro-5H-dibenzocyclohepten 
• 39654-52-9 trans-10,11-dibromo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one 
• 1210-34-0 dibenzosuberol 
• 2222-33-5 dibenzosuberenon 
• 1808-31-7 BS 7129 
• 1236-65-3 5-(4-chloro-benzylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene 
• 42866-41-1 1-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-1-phenyl-propan-2-one 
• 42866-55-7 (4-Chloro-phenyl)-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-acetaldehyde 
• 2732-90-3 5-methylene-10,11-dihydro-5H-dibenzo[a,d]cycloheptene 
• 42866-47-7 1-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-1-phenyl-butan-2-one 
• 5371-46-0 5-Hydroxy-5-(p-dimethylamino-phenyl)-10,11-dihydro-dibenzocyclohepten 
• 27980-51-4 4-(10,11-dihydrodibenzo[a,d]cyclohepten-5-ylidenemethyl)benzonitrile 

Related news

The effect of induced aromaticity on sorption of organic molecules by montmorillonite: Comparison of Dibenzosuberone (cas 1210-35-1) with dibenzotropone07/21/2019

Despite the close resemblance of the molecular structures of the two title compounds, major differences were found in their adsorption characteristics on Na, Cu, Mg, Ni, Fe, and Al montmorillonite. These differences are reflected in electronic and infrared (IR) spectra, in orientational IR spect...detailed

Relevant articles and documents

Decomposition of amitriptyline hydrochloride in aqueous solution: identification of decomposition products

The decomposition of amitriptyline hydrochloride upon autoclaving in a buffered solution (pH 6.8) was investigated. Three major decomposition products [3 (propa 1,3 dienyl) 1,2:4,5 dibenzocyclohepta 1,4 diene, dibenzosuberone, and 3 (2 oxoethylidene) 1,2:4,5 dibenzocyclohepta 1,4 diene] were detected and identified by chromatographic and spectroscopic techniques. Evidence is presented that the latter two compounds are formed by further oxidation of 3 (propa 1,3 dienyl) 1,2:4,5 dibenzocyclohepta 1,4 diene, and a possible decomposition pathway is outlined.

Productive chloroarene C-Cl bond activation: Palladium/phosphine-catalyzed methods for oxidation of alcohols and hydrodechlorination of chloroarenes

The palladium/phosphine-catalyzed productive chloroarene C-Cl bond activation provides general, efficient, and functional group friendly methods for the selective oxidation of alcohols and the hydrodechlorination of chloroarenes.

Excited State Carbon Acids: Base Catalysed Photoketonization of Dibenzosuberenol to Dibenzosuberone via Initial C-H Bond Heterolysis from S1

A new photoreaction, the photoketonization of dibenzosuberenol (1) to dibenzosuberone (2) in aqueous solution, is reported, the mechanism of which is believed to involve initial ionization of the C-H proton at the 5-position (in S1), to generate a 5-hydroxy-5-dibenzosuberenyl (9) carbanion intermediate.

Convenient synthesis of 2-(2-phenylethyl)benzoic acid: A key intermediate in the synthesis of dibenzosuberone

A convenient and improved synthesis of 2-(2-phenylethyl) benzoicacid, a key intermediate in the synthesis of dibenzosuberone is described.

Spectrophotometric determination of amitriptyline hcl in pure and pharmaceutical forms

Five spectrophotometric methods for determination of Amitriptyline HCl have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B and C are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue (BTB), Bromophenol blue (BPB) and Bromocresol purple (BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case. Method D depends upon charge transfer complexation of neutralized drug with iodine which produces iodide ion whose absorbance at 366 nm is measured as function of concentration of the drug. This complex, too, has 1:1 composition as determined by Job's method. Method E is developed on the basis of oxidation of the drug with alkaline KMnO4 which generates green colored manganate ion with ?max 610 nm. As the intensity of green color increased with increasing time kinetics of the reaction is followed and calibration curves are constructed by using initial rate and fixed time methods. Excellent recovery studies with high accuracy and precision indicate that the methods can be successfully used in industries for the assay of drug in pure form and pharmaceuticals.

Nafion-H catalysed intramolecular Friedel-Crafts acylation: Formation of cyclic ketones and related heterocycles

Benzoic acids with suitable substituents bearing phenyl ring in the ortho position undergo cyclization by intramolecular Friedel-Crafts acylation in the presence of Nafion-H, a perfluorinated resinsulfonic acid catalyst. Synthesis of anthraquinone, anthrone, fluorenone, α-tetralone, 1-benzosurberone and heterocycles such as acridone, xanthone etc. is easily achieved in good to excellent yields (82-95%) by this method.

Phase-Transfer Permanganate Oxidation of Unfunctionalized Benzylic Positions

The utility of potassium permanganate in a biphasic medium employing a phase-transfer catalyst is described for the selective oxidations of doubly-benzylic secondary carbons to ketones and doubly-benzylic tertiary carbons to alcohols as well as of singly-benzylic secondary alcohols to ketones.

Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation

An efficient nickel(ii)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstratedviathe facile oxidation of structurally complicated natural products.

Synthesis of dibenzocycloketones by acyl radical cyclization from aromatic carboxylic acids using methylene blue as a photocatalyst

An efficient intramolecular radical cyclization reaction via photoredox catalysis was developed for the synthesis of dibenzocycloketone derivatives using methylene blue as a photosensitizer. This strategy could be widely used to synthesize large heterocycles due to the unique reactivity of phosphoranyl radicals formed by a polar/SET crossover between an aromatic carboxylic acid and a phosphine radical cation. Attractive features of this process include generation of an acyl radical by an inexpensive and metal-free photocatalyst, which effectively undergoes a cyclization process.

Method for preparing amitriptyline intermediate by using solid acid catalyst

The invention relates to a method for preparing an amitriptyline intermediate by using a solid acid catalyst. The method for preparing the amitriptyline intermediate by using the solid acid catalyst can effectively solve the problem about green, clean and safe production of the amitriptyline intermediate. The method comprises the steps of adding o-phenethyl benzoic acid and ZSM-5 molecular sievesto a solvent of 5 to 20 times of the total mass of o-phenethyl benzoic acid and ZSM-5 molecular sieves at 0 to 40 DEG C, raising temperature to 60 to 100 DEG C, heating under reflux and stirring for 6to 12 hours, after cooling reaction liquid, filtering under reduced pressure, removing ZSM-5 molecular sieves through filtration, after washing filtrate with water, drying and concentrating to obtaina crude product of 10,11-dihydrodibenzo[a,b]cycloheptene-5-one, and conducting recrystallization with anhydrous ethanol to obtain a pure product of the amitriptyline intermediate. The method for preparing the amitriptyline intermediate can significantly reduce the emission of polluting waste in production, reduce the production cost, and is an innovation in the method for preparing the amitriptyline intermediate.