1217835-51-2

Basic information

• Product Name: ent-Calindol Amide
• Synonyms: ent-Calindol Amide;(S)-N-[1-(1-Naphthyl)ethyl]indole-2-carboxaMide;N-[(1S)-1-(1-Naphthalenyl)ethyl]-1H-Indole-2-carboxaMide
• CAS NO: 1217835-51-2
• Molecular Formula: C21H17N2O
• Molecular Weight: 313.37248
• Product Categories: Aromatics;Chiral Reagents;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Chiral Reagents, Indole Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1217835-51-2.mol

Chemical Properties

• Boiling Point: 620.2±38.0 °C(Predicted)
• Appearance: /
• Density: 1.236±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane, Dimethylformamide, Methanol,
• PKA: 14.86±0.46(Predicted)
• CAS DataBase Reference: ent-Calindol Amide(CAS DataBase Reference)
• NIST Chemistry Reference: ent-Calindol Amide(1217835-51-2)
• EPA Substance Registry System: ent-Calindol Amide(1217835-51-2)

Safety Data

• Hazardous Substances Data: 1217835-51-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate in the preparation of ent-Calindol

Upstream product

• 58881-45-1 Indole-2-carbonyl chloride 
• 3886-70-2 (R)-1-(1-Naphthyl)ethylamine 
• 1477-50-5 Indole-2-carboxylic acid 

Relevant articles and documents

N2-Benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1, 2-diamines and conformationally restrained indole analogues: Development of calindol as a new calcimimetic acting at the calcium sensing receptor

The synthesis and calcimimetic activities of two new families of compounds are described. The most active derivatives of the first family, N 2-(2-chloro-(or 4-fluoro-)benzyl)-N1-(1-(1-naphthyl)ethyl) -3-phenylpropane-1,2-diamine (4b

Novel calcium receptor active molecules and method for preparing same

The invention concerns compounds of general formula (I) wherein: the group X represents a —NR4, —CH═N or —CHR5-NR4-group; the group Y represents an oxygen or sulphur atom or a NR, —CR5, —CHR5-, —CR5=CR6- or —CHR5-CHR6 group provided that when group X represents the —CH═N— or —CHR5-NR4-group, group Y represents an oxygen or a sulphur atom or a Nr, —CR5 or —CHR group; the group R represents a hydrogen atom or an alkyl, aryl or aralkyl group; the groups R1, R5 and R6, identical or different, represent each a hydrogen or halogen atom or an alkyl or alkoxy group; the group R2 represents a hydrogen atom or an alkyl group; the group R3 represents an aryl group; and the group R4 represents a hydrogen atom, an alkyl, aryl, aralkyl, alkylsulphonamide, arylsulphonamide or aralkyl sulphonamide group; and their salt with a pharmaceutically acceptable acid, in the form of a racemic mixture and their optically pure isomer. The invention also concerns their preparation, pharmaceutical compositions containing them and their use as CaSR activity modulator and as medicine for preferably treating diseases or physiological disorders involving the intervention of CaSR activity modulation.