1228692-28-1Relevant academic research and scientific papers
New heterocyclic systems derived from pyridine: New substrates for the investigation of the azide/tetrazole equilibrium
Sirakanyan, Samvel N.,Spinelli, Domenico,Geronikaki, Athina,Hovakimyan, Anush A.,Noravyan, Azat S.
, p. 8648 - 8656 (2014)
By exploiting the reactivity of 7-alkyl-3-chloro-4-cyano-1-hydrazino-5,6,7,8-tetrahydro-2,7-naphthyridines 5 some 7-alkyl-1-azido-3-chloro-4-cyano-5,6,7,8-tetrahydro-2,7-naphthyridines 6 were synthesized. Looking at their chemical properties we have ascer
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists
Guo, Cheng,Guzzo, Peter R.,Hadden, Mark,Sargent, Bruce J.,Yet, Larry,Kan, Yanqing,Palyha, Oksana,Kelly, Theresa M.,Guan, Xiaoming,Rosko, Kim,Gagen, Karen,Metzger, Joseph M.,Dragovic, Jasminka,Lyons, Kathryn,Lin, Linus S.,Nargund, Ravi P.
scheme or table, p. 2785 - 2789 (2010/07/08)
The original structure of a high-throughput screening hit obtained from an external vendor was revised based on multiple NMR studies. The active compound was re-synthesized via a novel route and its structure and biological activity as a BRS-3 agonist were unambiguously confirmed. Multi-gram quantities of the hit were prepared for pharmacokinetic and efficacy studies. The synthetic strategy allowed for the preparation of multiple analogs for SAR exploration.
