123367-27-1

Basic information

• Product Name: 3-(diMethylaMino)-1-(pyridin-4-yl)prop-2-en-1-one
• Synonyms: 3-(diMethylaMino)-1-(pyridin-4-yl)prop-2-en-1-one
• CAS NO: 123367-27-1
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.21508
• Mol File: 123367-27-1.mol
• Article Data: 38

Chemical Properties

• Melting Point: 114℃ (ethyl acetate isopropyl ether )
• Boiling Point: 281.4±36.0 °C(Predicted)
• Appearance: /
• Density: 1.070±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.47±0.70(Predicted)
• CAS DataBase Reference: 3-(diMethylaMino)-1-(pyridin-4-yl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(diMethylaMino)-1-(pyridin-4-yl)prop-2-en-1-one(123367-27-1)
• EPA Substance Registry System: 3-(diMethylaMino)-1-(pyridin-4-yl)prop-2-en-1-one(123367-27-1)

Safety Data

• Hazardous Substances Data: 123367-27-1(Hazardous Substances Data)

Usage

General Description

3-(Dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one is a chemical compound with the molecular formula C12H14N2O. It is a yellow solid at room temperature and is commonly used as a reagent in organic synthesis. 3-(diMethylaMino)-1-(pyridin-4-yl)prop-2-en-1-one is a derivative of pyridine and contains a dimethylamino group, as well as a propenone functional group. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and ability to form various chemical bonds. Additionally, it is also used in the production of dyes and other specialty chemicals. However, it is important to handle this compound with care as it may be hazardous if not used properly.

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 898563-69-4 4-[2-(4-benzyloxy-phenyl)-2H-pyrazol-3-yl]-pyridine 
• 874779-72-3 4-(pyridin-4-yl)pyrimidine-2-thiol 
• 166196-54-9 4-(4-bromo-1H-pyrazol-3-yl)pyridine 

Relevant articles and documents

Chiral coordination polymers based on thallium(I) complexes of new bis- and tris(pyrazolyl)borate ligands with externally-directed 4-pyridyl groups

The new ligands dihydro-bis[3-(4-pyridyl)pyrazol-1-yl]borate (Bp 4py) and hydro-tris[3-(4-pyridyl)pyrazol-1-yl]borate (Tp 4py) are derivatives of the well known bis- and tris(pyrazolyl) borate cores, bearing 4-pyridyl substituents attached to the pyrazolyl C 3 positions; crystal structures of the Tl(I) complexes show that both are infinite one-dimensional polymeric chains, in which the Tl(I) centre within each bis-pyrazolyl or tris-pyrazolyl cavity is also connected to a pendant 4-pyridyl residue from an adjacent complex unit to build up the chain.

Design, synthesis, structure elucidation, and biological activities of 3-(substituted amino)-1-(pyridin-4-yl)propenones and 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidine–adamantane hybrids

Abstract: Novel molecular hybrids of 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidine–adamantane have been synthesized in excellent yields by the reaction of enaminones, 1-adamantanamine, and formaldehyde. Enaminones (Z)-3-alkyl/aralkyl/aryl-1-(pyridin-4-yl)prop-2-en-1-ones have been synthesised by the reaction of 4-acetylpyridine with N,N-dimethylformamide dimethyl acetal and its bioassay test showed good anti-inflammatory property, but no zone of growth inhibition against Bacillus subtilis (MTCC Code-121), Staphylococcus aureus (MTCC Code-9886), Escherichia coli (MTCC Code-1302), and Salmonella enterica (MTCC Code-3232) bacterial strains. The structures of the synthesized compounds have been established with the help of spectral and analytical data. X-ray analysis of a representative candidate of the series 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidine–adamantane was done for the final confirmation of the structure.

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Microwave-Assisted Synthesis of Fluorescent Pyrido[2,3-b]indolizines from Alkylpyridinium Salts and Enaminones

Pyridinium ylides are well recognized as dipoles for cycloaddition reactions. In its turn, the microwave-assisted interaction of N-(cyanomethyl)-2-alkylpyridinium salts with enaminones unexpectedly proceeds as a domino sequence of cycloisomerization and cyclocondensation reactions, instead of a 1,3-dipolar cycloaddition. The reaction takes place in the presence of sodium acetate as base and employs benign solvents. The optical properties of the resulting pyrido[2,3-b]indolizines were studied, showing green light emission with high fluorescence quantum yields.