1260878-78-1

Basic information

• Product Name: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE
• Synonyms: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE;4-chloro-3-fluoropicolinaldehyde
• CAS NO: 1260878-78-1
• Molecular Formula: C6H3ClFNO
• Molecular Weight: 159.5455232
• Mol File: 1260878-78-1.mol

Chemical Properties

• Boiling Point: 196.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.444±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -0.69±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE(1260878-78-1)
• EPA Substance Registry System: 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE(1260878-78-1)

Safety Data

• Hazardous Substances Data: 1260878-78-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE is utilized as an intermediate in the synthesis of various pharmaceuticals, contributing to the creation of new medicinal agents. Its unique structure allows for the formation of heterocyclic compounds, which are often found in biologically active molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE serves as a key intermediate in the production of agrochemicals, playing a role in the development of compounds that can protect crops and enhance agricultural productivity.
Used in Fine Chemicals Synthesis:
4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE is also employed in the synthesis of other fine chemicals, where its reactivity and structural features are leveraged to produce specialty chemicals for various applications.
Used as a Building Block in Medicinal Chemistry:
Recognized for its potential, 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE is used as a building block in the field of medicinal chemistry, facilitating the design and synthesis of novel pharmaceutical agents with improved therapeutic properties.
It is important to handle 4-CHLORO-3-FLUOROPYRIDINE-2-CARBALDEHYDE with care due to its reactivity and potential health hazards, ensuring safety in its applications across different industries.

Upstream product

• 109-72-8 n-butyllithium 
• 2546-56-7 4-chloro-3-fluoro-pyridine 
• 399-88-2 3-fluoro-4-methylpyridine 
• 91837-43-3 1,3-dioxoisoindolin-2-yl (tert-butoxycarbonyl)glycinate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1422511-05-4 phenyl ((3R)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-chloro-3-fluoropyridin-2-yl)propyl)((10R,14S)-5-((methoxycarbonyl)amino)-10-methyl-9-oxo-16-((2-(trimethylsilyl)ethoxy)methyl)-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-14-yl)carbamate 
• 1422510-25-5 (S)-phenyl (1-(4-chloro-3-fluoropyridin-2-yl)-3-oxopropyl)carbamate 
• 1422510-27-7 (S)-phenyl (1-(4-chloro-3-fluoropyridin-2-yl)but-3-en-1-yl)carbamate 

Relevant articles and documents

HETEROARYL PLASMA KALLIKREIN INHIBITORS

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

PLASMA KALLIKREIN INHIBITORS AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Regioselective amidomethylation of 4-chloro-3-fluoropyridine by metalation and minisci-type reactions

The synthesis of a series of 2-amidomethylated pyridines (3-8) was investigated, starting from 4-chloro-3- fluoropyridine. Kinetic deprotonation at -75 °C followed by reaction with DMF gave 2-formyl-4-chloro-3-fluoropyridine 10 regioselectively, which was converted to 2-aminomethyl analogue 1 via sulfinamide 2. Alternatively, Minisci-type amidomethylation under Ag+/persulfate or photoredox-mediated conditions using a series of amino acid derivatives gave (3-8, 19, and 34) in 30-74% yield and isomer ratios in the range 6.7:1 to >50:1. The latter methods gave overall yields similar to that of the deprotonation approach, but were shorter and more amenable to scale-up. In particular, N-Boc analogue 8 was obtained in a single step. The amidomethylations of another six 3-fluoropyridines under the photoredox conditions were briefly examined.

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.