127263-13-2

Basic information

• Product Name: zamifenacin
• Synonyms: zamifenacin;(+/-)-1-(2-(1,3-Benzodioxol-5-yl)ethyl)-3-(diphenylmethoxy)piperidine;(3-DiphenylMethoxy-1-(3,4)-Methylenedioxyphenethyl)piperidine;(3R)-1-[2-(1,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidine
• CAS NO: 127263-13-2
• Molecular Formula: C₂₇H₂₉NO₃
• Molecular Weight: 415.52
• Mol File: 127263-13-2.mol

Chemical Properties

• Boiling Point: 532.5°Cat760mmHg
• Flash Point: 145.6°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 2.04E-11mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: zamifenacin(CAS DataBase Reference)
• NIST Chemistry Reference: zamifenacin(127263-13-2)
• EPA Substance Registry System: zamifenacin(127263-13-2)

Safety Data

• Hazardous Substances Data: 127263-13-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Zamifenacin is used as a therapeutic agent for managing overactive bladder and urinary incontinence due to its ability to block acetylcholine and reduce the contraction of smooth muscles in the bladder. This results in decreased urgency and frequency of urination, providing relief to patients suffering from these conditions.
Additionally, its longer duration of action facilitates once-daily dosing, which can improve patient compliance and overall treatment effectiveness. However, it is crucial to adhere to the prescribed dosage and be aware of potential side effects such as dry mouth, constipation, blurred vision, and urinary retention to ensure safe and effective use of zamifenacin.

InChI:InChI=1/C27H29NO3/c1-3-8-22(9-4-1)27(23-10-5-2-6-11-23)31-24-12-7-16-28(19-24)17-15-21-13-14-25-26(18-21)30-20-29-25/h1-6,8-11,13-14,18,24,27H,7,12,15-17,19-20H2/t24-/m1/s1

Upstream product

• 90-99-3 diphenylchloromethane 
• 25379-88-8 2-(3,4-dihydroxyphenyl)acetic acid methyl ester 
• 102-32-9 3,4-dihydroxyphenylacetate 
• 326-59-0 benzo[1,3]dioxol-5-yl-acetic acid methyl ester 
• 1086135-98-9 2-benzo[1,3]dioxol-5-yl-1-(3-hydroxy-piperidin-1-yl)-ethanone 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 
• 1086136-00-6 1-(2-benzo[1,3]dioxol-5-yl-ethyl)-piperidin-3-ol 

Related news

A SHORT AND EFFICIENT SYNTHESIS OF zamifenacin (cas 127263-13-2) A MUSCARINIC M3 RECEPTOR ANTAGONIST08/06/2019

A short synthesis of zamifenacin is described by using a ring enlargement of a l-prolinol derivative. © 1997 Elsevier Science Ltd.detailed

Characterization of the interaction of zamifenacin (cas 127263-13-2) at muscarinic receptors in vitro08/05/2019

The interaction of zamifenacin ((3R)-(+)-diphenylmethoxy-1-(3,4)-methylenedioxyphenethyl)piperidine) at muscarinic receptor subtypes was studied using radioligand binding and functional techniques, in vitro. In radioligand binding studies, zamifenacin acted as a competitive antagonist, with the ...detailed

Relevant articles and documents

Oxyamination of Unactivated Alkenes with Electron-Rich Amines and Acids via a Catalytic Triiodide Intermediate

An aerobic catalytic oxidation process is described for the olefin oxyamination using acids and primary amines as the sources of O and N. Our mechanistic findings point to the formation of triiodide as a critical catalytic intermediate to account for the

DEUTERATED ZAMIFENACIN DERIVATIVES

Disclosed herein are substituted piperidine-based muscarinic receptor modulators of Formula (I), process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. At least one of the R groups is a deuterium atom.