129303-82-8 Usage
General Description
1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridine, also known as Cymbidazol, is a heterocyclic compound with a molecular formula C11H8N4. This chemical is commonly used in the pharmaceutical industry as a potential antitumor and antiviral agent. It is structurally similar to purine bases and has been investigated for its potential inhibitory effects on enzymes involved in DNA replication and repair. Additionally, this compound has shown potential in the treatment of certain viral infections by targeting viral RNA polymerase. The unique chemical structure and potential biological activities make 1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridine an interesting candidate for further research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 129303-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,3,0 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 129303-82:
(8*1)+(7*2)+(6*9)+(5*3)+(4*0)+(3*3)+(2*8)+(1*2)=118
118 % 10 = 8
So 129303-82-8 is a valid CAS Registry Number.
129303-82-8Relevant articles and documents
Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists
Savall, Brad M.,Wu, Duncan,De Angelis, Meri,Carruthers, Nicholas I.,Ao, Hong,Wang, Qi,Lord, Brian,Bhattacharya, Anindya,Letavic, Michael A.
, p. 671 - 676 (2015)
We describe the synthesis and SAR of 1,2,3-triazolopiperidines as a novel series of potent, brain penetrant P2X7 antagonists. Initial efforts yielded a series of potent human P2X7R antagonists with moderate to weak rodent potency, some CYP inhibition, poo
P2X7 MODULATORS
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Paragraph 0440; 0441, (2014/09/29)
The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.
