98175-84-9

Upstream product

• 35826-31-4 3-amino-4-(phenylamino)pyridine 
• 35750-90-4 4-(N-phenylamino)-3-nitropyridine 
• 62-53-3 aniline 
• 13091-23-1 4-chloro-3-nitropyridine 
• 273-05-2 1H-[1.2.3]triazolo-(4,5-c)pyridine 
• 591-50-4 iodobenzene 
• 129303-82-8 1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridine 

Relevant academic research and scientific papers

Reduction of imidazo[4,5-c]pyridine and [1,2,3]triazolo[4,5-c]pyridine derivatives to spinaceamines and 2-azaspinaceamines

Reduction of 1-substituted [1,2,3]triazolo[4,5-c]pyridines with nickel-aluminum alloy in aqueous alkali gave 2-azaspinaceamines. Reduction of imidazo[4,5-c]pyridine and [1,2,3]triazolo[4,5-c]pyridine derivatives with formic acid in the presence of triethy

BICYCLIC HETEROCYCLIC DERIVATIVES

Compounds of the formula la or of the formula lb in which X, Y, R1 and R2 have the meanings indicated in Claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists

We describe the synthesis and SAR of 1,2,3-triazolopiperidines as a novel series of potent, brain penetrant P2X7 antagonists. Initial efforts yielded a series of potent human P2X7R antagonists with moderate to weak rodent potency, some CYP inhibition, poo

P2X7 MODULATORS

The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.

SYNTHESIS OF DERIVATIVES OF 2-AZASPINACEAMINE

1,5-Disubstituted 1,2,3-triazolopyridinium monoquaternary salts were obtained by the reaction of 1-substituted 1,2,3-triazolopyridines with alkyl halides and bromomethyl ketones.Their reduction with sodium borohydride in an alcohol medium led to the formation of derivatives of both 1,5-dialkyl- and N5-β-hydroxyethyl-β-aryl(alkyl)-2-azaspinaceamine.It was shown that 1-alkyl-5-(β-hydroxy-β-phenylethyl)-2-azaspinaceamines containing a methoxy group at the para position of the phenyl ring are readily cleaved at the terminal C-N5 bond when heated with hydrochloric acid in water-alcohol solution and form 1-alkyl-2-azaspinaceamines.