1300031-62-2Relevant articles and documents
METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
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Paragraph 00616; 00754; 00755; 00756, (2021/08/13)
The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.
QUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS
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Page/Page column 26; 27, (2016/12/07)
Provided is a novel quinoline derivative inhibiting the bromodomain and extra terminal domain (BET) proteins, and a pharmaceutical composition comprising the same which can be useful for prevention or treatment of a precancerous transformation or a cancer.
7-(3,5-Dimethyl-4-Isoxazolyl)-8-(Methyloxy)-1H-Imidazo[4,5-C]Quinoline Derivatives
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Paragraph 0178-0179, (2014/03/21)
Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
4-(8-METHOXY-1-((1-METHOXYPROPAN-2-YL)-2-(TETRAHYDRO-2H-PYRAN-4-YL)-1 H-IMIDAZO[4,5-C]QUINOLIN-7-YL)-3,5-DIMETHYLISOXAZOLE AND ITS USE AS BROMODOMAIN INHIBITOR
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, (2013/03/26)
Novel quinoline compounds of formula (I), pharmaceutical compositions containing such compounds and their use in therapy, as bromodomain inhibitors.
NOVEL COMPOUNDS
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Page/Page column 30-31, (2012/11/07)
Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
Imidazo [4, 5-C] Quinoline Derivatives As Bromodomain Inhibitors
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Page/Page column 18, (2012/09/22)
Novel compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151
Mirguet, Olivier,Lamotte, Yann,Donche, Frédéric,Toum, Jér?me,Gellibert, Franoise,Bouillot, Anne,Gosmini, Romain,Nguyen, Van-Loc,Delannée, Delphine,Seal, Jonathan,Blandel, Florence,Boullay, Anne-Bénédicte,Boursier, Eric,Martin, Sandrine,Brusq, Jean-Marie,Krysa, Gael,Riou, Alizon,Tellier, Rémi,Costaz, Agns,Huet, Pascal,Dudit, Yann,Trottet, Lionel,Kirilovsky, Jorge,Nicodeme, Edwige
supporting information; experimental part, p. 2963 - 2967 (2012/06/04)
The discovery, synthesis and biological evaluation of a novel series of 7-isoxazoloquinolines is described. Several analogs are shown to increase ApoA1 expression within the nanomolar range in the human hepatic cell line HepG2.
IMIDAZO [4, 5-C] QUINOLINE DERIVATES AS BROMODOMAIN INHIBITORS
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Page/Page column 41-42, (2011/06/11)
Novel compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.