130089-98-4

Basic information

• Product Name: NQ301
• Synonyms: NQ301
• CAS NO: 130089-98-4
• Molecular Formula: C18H12ClNO3
• Molecular Weight: 325.75
• Mol File: 130089-98-4.mol

Chemical Properties

• Melting Point: 241-243 °C(Solv: ethanol (64-17-5))
• Boiling Point: 476.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -5.25±0.20(Predicted)
• CAS DataBase Reference: NQ301(CAS DataBase Reference)
• NIST Chemistry Reference: NQ301(130089-98-4)
• EPA Substance Registry System: NQ301(130089-98-4)

Safety Data

• RIDADR: UN 3077 9 / PGIII
• Hazardous Substances Data: 130089-98-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
NQ301 is used as an antithrombotic agent for its ability to inhibit platelet aggregation. This property makes it a promising candidate for the development of treatments aimed at preventing blood clot formation, which can lead to conditions such as stroke, heart attack, and deep vein thrombosis.
NQ301 is used as a research tool for studying the mechanisms underlying platelet aggregation and thrombus formation. Its ability to inhibit platelet aggregation induced by various stimuli can help researchers better understand the complex processes involved in blood clotting and identify potential targets for therapeutic intervention.

Biochem/physiol Actions

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.

Upstream product

• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 99-92-3 p-aminobenzophenone 

Relevant articles and documents

Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives

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Spectroscopic and theoretical studies on the nucleophilic substitution of 2,3-dichloronaphthoquinone with para-substituted anilines in solid state via initial charge transfer complexation

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