13053-82-2

Basic information

• Product Name: N-(1,3-thiazol-2-yl)benzamide
• Synonyms: N-(1,3-thiazol-2-yl)benzamide
• CAS NO: 13053-82-2
• Molecular Weight: 204.252
• Mol File: 13053-82-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: N-(1,3-thiazol-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,3-thiazol-2-yl)benzamide(13053-82-2)
• EPA Substance Registry System: N-(1,3-thiazol-2-yl)benzamide(13053-82-2)

Safety Data

• Hazardous Substances Data: 13053-82-2(Hazardous Substances Data)

Upstream product

• 96-50-4 2-thiazolylamine 
• 93-99-2 benzoic acid phenyl ester 
• 15226-74-1 dicobalt octacarbonyl 
• 591-50-4 iodobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 1934-92-5 N-methyl-N-phenyl-benzamide 
• 65-85-0 benzoic acid 
• 611-74-5 N,N-dimethylbenzamide 
• 615-42-9 1,2-Diiodobenzene 
• 124-38-9 carbon dioxide 
• 93-58-3 benzoic acid methyl ester 
• 100-46-9 benzylamine 
• 35977-95-8 1-bromo-2-oxo-2-phenylethyl cyanide 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 132380-95-1 1-(1,3-thiazol-2-yl)-5-phenyltetrazole 
• 118215-05-7 N-Thiazol-2-yl-thiobenzamide 
• 473907-50-5 Re(N₂CO(C₆H₅))(P(C₆H₅)3)2Cl(C₃H₂NSNC(O)C₆H₅) 
• 473907-48-1 Re(P(C₆H₅)3)2Cl(CO)(C₆H₅CONC₃H₂NS) 
• 51579-06-7 2-phenyl-1,3-thiazolo<3,2-b><1,2,4>triazole 
• 50979-41-4 8-benzyl-6-methyl-5,7-dioxo-5,6,7,8-tetrahydro-thiazolo[3,2-a]pyrimidinylium betaine 
• 50979-36-7 8-benzyl-5,7-dioxo-5,6,7,8-tetrahydro-thiazolo[3,2-a]pyrimidinylium betaine 
• 51578-92-8 3-amino-2-benzoylamino-thiazolium; 2,4,6-trimethyl-benzenesulfonate 
• 41593-98-0 N-benzylthiazol-2-amine 

Relevant articles and documents

A novel and efficient amidation of 2-aminothiazole

A facile and efficient method has been developed for the synthesis of novel thiazolyl carboxamide derivatives by direct reaction of the corresponding esters and 2-aminothiazole. Treatment of 2-aminothiozole with various carboxylic esters in the presence of t-butylmagnesium chloride provides the biologically significant thiazolyl carboxamide derivatives in good to excellent yields.

Co2(CO)8as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines

Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd-Co(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents

Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti-inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFα and IL-8 release with IC50 values in μM range without cytotoxic activity.

N-(thiazol-2-yl)benzamide derivatives as a new series of supramolecular gelators: Role of methyl functionality and S?O interaction

A new series of N-(thiazol-2-yl) benzamide derivatives were synthesized, characterized and investigated for their gelation behavior with the aim to elucidate the role of methyl functionality and multiple non-covalent interactions on gelation/non-gelation