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Cas Database

13080-75-6

13080-75-6

Identification

  • Product Name:Ethanone,1-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-

  • CAS Number: 13080-75-6

  • EINECS:

  • Molecular Weight:237.301

  • Molecular Formula: C16H15 N O

  • HS Code:2933990090

  • Mol File:13080-75-6.mol

Synonyms:5H-Dibenz[b,f]azepine,5-acetyl-10,11-dihydro- (6CI,7CI,8CI,9CI);1-(10,11-Dihydrodibenz[b,f]azepin-5-yl)ethanone;5-Acetyl-10,11-dihydro-5H-dibenz[b,f]azepine;5-Acetyl-10,11-dihydro-5H-dibenzo[b,f]azepine

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:5-Acetyl-10,11-dihydro-5H-dibenzo[b,f]azepine
  • Packaging:1g
  • Price:$ 460
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:5-Acetyl-10,11-dihydro-5H-dibenzo[b,f]azepine
  • Packaging:1g
  • Price:$ 150
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 5 Articles be found

An improved method for the preparation of 3-substituted 10,11-dihydro-5H-[b,f] azepine derivatives

Csende, Ferenc,Hosztafi, Sándor

, p. 587 - 589 (1997)

-

SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR

-

Paragraph 00552, (2016/05/24)

The compounds of the invention are antagonists of CAR, with specificity for CAR over other proteins including PXR. The disclosed compounds are useful in treating or controlling cell proliferative disorders, in particular oncological disorders, such as cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

A novel porphyrazine ligand tailored to homogeneous metal catalyzed transformations

Parravicini, Matteo,Vaghi, Luca,Cravotto, Giancarlo,Masciocchi, Norberto,Maspero, Angelo,Palmisano, Giovanni,Penoni, Andrea

, p. 72 - 85 (2014/12/10)

A novel centrosymmetric porphyrazine (Pz) 1 decorated with pyrazino-dibenzo[b,f]azepine units have been prepared via Linstead macrocyclization reaction of a dinitrile precursor. Accordingly, the peripheral azepine nitrogen offers a chemical handle for sub

Reduction of diaryl alkenes by hypophosphorous acid-iodine in acetic acid

Fry, Albert J.,Allukian, Myron,Williams, Allison D.

, p. 4411 - 4415 (2007/10/03)

A mixture of 50% aqueous H3PO2 and I2 (in catalytic amount) in HOAc efficiently reduces aryl alkenes to the corresponding alkanes in high yield. Addition of acetic anhydride to the medium results in ring-acetylation (or N-acetylation in the case of amines). H3PO2 costs only one-fifth as much as hydriodic acid on a mole basis and one mole of H3PO2 produces four moles of HI, resulting in a 20-fold cost advantage for H3PO2/I2 over aqueous HI as a source of HI.

3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl and salts thereof

-

, (2008/06/13)

3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl, and its salts, prepared, inter alia, by heating 3-cyano-iminodibenzyl-5-carboxylic acid (N,N-dimethylaminopropyl ester) are described. The end product and its salts are useful as antidepressants.

Process route upstream and downstream products

Process route

dibenzo<b,f>azepine
256-96-2

dibenzoazepine

acetic acid
64-19-7,77671-22-8

acetic acid

9-methyl-acridine
611-64-3

9-methyl-acridine

5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

9-methyl-9,10-dihydroacridine
4217-52-1

9-methyl-9,10-dihydroacridine

9,10-dihydrodibenz<b,f>azepine
494-19-9

9,10-dihydrodibenzazepine

Conditions
Conditions Yield
With iodine; hypophosphorous acid; for 96h; Heating;
47%
18%
20%
9%
3-amino-5-acetyl-10,11-dihydro-5H-dibenz<b,f>azepine
84803-67-8

3-amino-5-acetyl-10,11-dihydro-5H-dibenzazepine

5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

3-phenyl-5-acetyl-10,11-dihydro-5H-dibenz[b,f]azepine

3-phenyl-5-acetyl-10,11-dihydro-5H-dibenz[b,f]azepine

Conditions
Conditions Yield
With isopentyl nitrite; 1) r.t., 20 min, 2) reflux, 2 h;
10%
26%
9,10-dihydrodibenz<b,f>azepine
494-19-9

9,10-dihydrodibenzazepine

acetic anhydride
108-24-7

acetic anhydride

5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

Conditions
Conditions Yield
for 3h; Reflux;
95%
With acetic acid; at 110 ℃; for 2h;
84%
3-amino-5-acetyl-10,11-dihydro-5H-dibenz<b,f>azepine
84803-67-8

3-amino-5-acetyl-10,11-dihydro-5H-dibenzazepine

5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

Conditions
Conditions Yield
With isopentyl nitrite; In N,N-dimethyl-formamide; Ambient temperature;
64%
9,10-dihydrodibenz<b,f>azepine
494-19-9

9,10-dihydrodibenzazepine

acetyl chloride
75-36-5

acetyl chloride

5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

Conditions
Conditions Yield
In ethanol; water; toluene;
5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

Conditions
Conditions Yield
aus Iminodibenzyl, Acetylchlorid;
aus 5-Acetyl-iminostilben, H2, Pd-Kohle;
10.11-Dihydro-dibenzoazepin, sd. Acetylchlorid;
Iminodibenzyl (II), CH3-COCl;
aus CH3COCl mit d. entspr. Amin;
5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

9,10-dihydrodibenz<b,f>azepine
494-19-9

9,10-dihydrodibenzazepine

Conditions
Conditions Yield
With triethyl borane; sodium hydroxide; In tert-butyl methyl ether; at 80 ℃; for 6h; Inert atmosphere; Sealed tube;
99%
5-acetyliminodibenzyl; With Triethoxysilane; sodium triethylborohydride; In tert-butyl methyl ether; at 80 ℃; for 6h;
With hydrogenchloride; In tert-butyl methyl ether; water; at 20 ℃; for 1h; chemoselective reaction;
99%
Multi-step reaction with 2 steps
1: potassium hydroxide; triethyl borane / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
2: sodium hydroxide; water / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
With triethyl borane; water; potassium hydroxide; sodium hydroxide; In tetrahydrofuran;
5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

9,10-dihydrodibenz<b,f>azepine
494-19-9

9,10-dihydrodibenzazepine

11-ethyliminodibenzyl
40583-88-8

11-ethyliminodibenzyl

ethanol
64-17-5

ethanol

Conditions
Conditions Yield
With Mo2((1)-H)2(OtBu)6; diphenylsilane; In toluene; for 25h; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique; Reflux;
62%
36%
5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

9,10-dihydrodibenz<b,f>azepine
494-19-9

9,10-dihydrodibenzazepine

11-ethyliminodibenzyl
40583-88-8

11-ethyliminodibenzyl

Conditions
Conditions Yield
With C37H54Cl2N2RhSi; phenylsilane; In toluene; at 20 ℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique;
78 %Chromat.
9 %Chromat.
5-acetyliminodibenzyl
13080-75-6

5-acetyliminodibenzyl

11-ethyliminodibenzyl
40583-88-8

11-ethyliminodibenzyl

ethanol
64-17-5

ethanol

Conditions
Conditions Yield
With diphenylsilane; Mo2(O-t-Bu)6; In toluene; at 111 ℃; for 25h; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique;

Global suppliers and manufacturers

Global( 9) Suppliers
  • Company Name
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  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • GIHI CHEMICALS CO.,LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86217390
  • Emails:info@gihichem.com
  • Main Products:66
  • Country:China (Mainland)
  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:82
  • Country:China (Mainland)
  • BOC Sciences
  • Business Type:Trading Company
  • Contact Tel:1-631-485-4226
  • Emails:sales@bocsci.com
  • Main Products:41
  • Country:United States
  • NovaChemistry
  • Business Type:Trading Company
  • Contact Tel:+44 (0)208 191 7890
  • Emails:info@novachemistry.com
  • Main Products:1
  • Country:United Kingdom
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