1316847-95-6Relevant articles and documents
Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics
Raghuraman, Arjun,Ko, Eunhwa,Perez, Lisa M.,Ioerger, Thomas R.,Burgess, Kevin
, p. 12350 - 12353 (2011/10/02)
Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/β-turn/sheet motif.