132-21-8 Usage
Uses
Used in Pharmaceutical Industry:
DEXBROMPHENIRAMINE is used as an antihistaminic agent for the symptomatic relief of allergic conditions, such as rhinitis and conjunctivitis. It functions as a histamine H1 receptor antagonist, blocking the effects of histamine and providing relief from allergy symptoms.
Used in Allergy Treatment:
DEXBROMPHENIRAMINE is used as a treatment for allergic conditions, including rhinitis and conjunctivitis, due to its ability to block histamine H1 receptors and alleviate allergy symptoms.
Brand Name:
DEXBROMPHENIRAMINE is marketed under the brand name Disomer by Schering.
Originator
Disomer,White,US,1959
Manufacturing Process
The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3-
(2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at
room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent
using 5 ml there of per gram of solid. Three subsequent crystallizations from
80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in
dimethylformamide).The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is
obtained from this salt with diethyl ether and aqueous potassium carbonate;
[α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then
reacted with maleic acid.
Therapeutic Function
Antihistaminic
Check Digit Verification of cas no
The CAS Registry Mumber 132-21-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 132-21:
(5*1)+(4*3)+(3*2)+(2*2)+(1*1)=28
28 % 10 = 8
So 132-21-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
