132577-30-1

Basic information

• Product Name: 4-[1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenyl methyl ether
• Synonyms: 4-[1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenyl methyl ether
• CAS NO: 132577-30-1
• Molecular Formula: C₁₈H₁₇ClN₂O₂
• Molecular Weight: 328.79278
• Mol File: 132577-30-1.mol

Chemical Properties

• Melting Point: 136 °C(Solv: ethanol (64-17-5))
• Boiling Point: 467.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• PKA: -1.53±0.70(Predicted)
• CAS DataBase Reference: 4-[1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenyl methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenyl methyl ether(132577-30-1)
• EPA Substance Registry System: 4-[1-acetyl-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenyl methyl ether(132577-30-1)

Safety Data

• Hazardous Substances Data: 132577-30-1(Hazardous Substances Data)

Upstream product

• 6552-63-2 4'-chloro-4-methoxy-chalcone 
• 64-19-7 acetic acid 
• 85502-87-0 (E)-4'-chloro-4-methoxychalcone 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors

Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative bacteria. Fifty-six 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives were synthesized and developed as potent inhibitors of FabH. This inhibitor class demonstrates strong antibacterial activity. Escherichia coli FabH inhibitory assay and docking simulation indicated that the compounds 1-(5-(4-fluorophenyl)- 3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone (12) and 1-(5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone (13) were potent inhibitors of E. coli FabH.

Microwave assisted synthesis of 2-pyrazolines

A simple and efficient method has been developed for the rapid synthesis of 1-acetyl-3, 5-diaryl-2-pyrazolines 2 from chalcones 1 and hydrazine hydrate in unmodified domestic microwave oven in unsealed borosil vessels using acetic acid as energy transfer medium. Rate enhancement with improved yield, a characteristic of the synthesis under microwave irradiation has been observed in the present paper. The compounds synthesised have been characterised and compared with samples prepared by thermal methods.