132924-59-5

Basic information

• Product Name: 3-[(4-Chlorophenyl)thio]-1-(diphenylmethyl)azetidine
• Synonyms: 3-[(4-Chlorophenyl)thio]-1-(diphenylmethyl)azetidine;1-benzhydryl-3-(4-chlorophenyl)sulfanylazetidine
• CAS NO: 132924-59-5
• Molecular Formula: C₂₂H₂₀ClNS
• Molecular Weight: 365.9189
• Mol File: 132924-59-5.mol

Chemical Properties

• Boiling Point: 477.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 6.40±0.10(Predicted)
• CAS DataBase Reference: 3-[(4-Chlorophenyl)thio]-1-(diphenylmethyl)azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-Chlorophenyl)thio]-1-(diphenylmethyl)azetidine(132924-59-5)
• EPA Substance Registry System: 3-[(4-Chlorophenyl)thio]-1-(diphenylmethyl)azetidine(132924-59-5)

Safety Data

• Hazardous Substances Data: 132924-59-5(Hazardous Substances Data)

Upstream product

• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 108-20-3 di-isopropyl ether 
• 6153-56-6 oxalic acid dihydrate 
• 124-63-0 methanesulfonyl chloride 
• 106-54-7 p-Chlorothiophenol 
• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 

Downstream Products

• 848643-97-0 1-benzhydryl-3-(4-chloro-benzenesulfinyl)-azetidine 
• 1340259-48-4 3-(4-chloro-phenylsulfanyl)-azetidine 
• 132924-61-9 3-[(4-chlorophenyl)thio]-1-azetidinecarbonyl chloride 

Relevant articles and documents

1,3-DISUBSTITUTED AZETIDINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES

Compounds of formula Ia or Ib in free or salt form, wherein Ar, X1, X2, m, R1, Q, Y, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by CCR-3, for example an inflammatory or allergic cond

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides

A method of treating animals to obtain muscle relaxation and/or to relieve anxiety is disclosed utilizing novel and known 3-aryloxy and 3-arylthioazetidinecarboxamides having the formula: STR1 wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo substituted pyridyl, phenyl or substituted phenyl; R1 and R2 are hydrogen, loweralkyl, aryl, allyl groups, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl and diloweralkylaminoalkyl, and R1 and R2 when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical; R3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof and pharmaceutical salts thereof and hydrates thereof when they are possible.

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides

A method of treating animals to obtain muscle relaxation and/or to relieve anxiety is disclosed utilizing novel and known 3-aryloxy and 3-arylthioazetidinecarbonxamides having the formula: STR1 wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo substituted pyridyl, phenyl or substituted phenyl; R1 and R2 are hydrogen, loweralkyl, aryl, allyl groups, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloakylloweralkyl, arylloweralkyl and diloweralkylaminoalkyl, and R1 and R2 when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical; R3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof and pharmaceutical salts thereof and hydrates thereof when they are possible.

3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics

Novel 3-aryloxy and 3-arylthioazetidinecarboxamides having utility in a method of treating convulsions and epilepsy and compositions therefor are disclosed having the formula: STR1 wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo-substituted-pyridyl, phenyl or substituted phenyl; R1 and R2 are selected from hydrogen, loweralkyl, aryl, allyl, substituted allyl, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl, diloweralkylaminoloweralkyl, and R1 and R2 when taken with the adjacent nitrogen atom may form a heterocyclic radical; R3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof, excepting that when R3 is hydrogen, Z is oxygen, B is oxygen, and Ar is phenyl or phenyl substituted by trifluoromethyl or aminocarbonyl, then R1 and R2 cannot be a combination of hydrogen and loweralkyl, and the further exception that when R3 is hydrogen, Z is oxygen, B is oxygen, and Ar is phenyl or phenyl substituted by fluoro, loweralkyl, loweralkoxy, trifluoromethyl, acetyl, or aminocarbonyl, then R1 and R2 cannot both be hydrogen.