13472-57-6

Basic information

• Product Name: 2,6-Diethoxypyridine
• Synonyms: 2,6-Diethoxypyridine
• CAS NO: 13472-57-6
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.20502
• Mol File: 13472-57-6.mol

Chemical Properties

• Melting Point: 21.5 °C
• Boiling Point: 220.0±20.0 °C(Predicted)
• Appearance: /
• Density: 1.021±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.84±0.24(Predicted)
• CAS DataBase Reference: 2,6-Diethoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Diethoxypyridine(13472-57-6)
• EPA Substance Registry System: 2,6-Diethoxypyridine(13472-57-6)

Safety Data

• Hazardous Substances Data: 13472-57-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2,6-Diethoxypyridine is used as a building block for the synthesis of pharmaceuticals. Its ethoxy groups allow for the introduction of the diethoxypyridine moiety into various organic molecules, contributing to the development of new drugs.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2,6-Diethoxypyridine serves as a key component in the creation of various agrochemicals. Its reactivity and ability to be incorporated into complex molecules make it valuable for the development of effective agricultural products.
Used in Organic Synthesis:
2,6-Diethoxypyridine is utilized as an effective reagent in organic synthesis. Its ethoxy groups facilitate the introduction of the diethoxypyridine moiety into a wide range of organic compounds, enhancing the versatility of organic chemistry research and product development.

Upstream product

• 4645-11-8 6-ethoxy-2-bromo-pyridine 
• 141-52-6 sodium ethanolate 
• 2402-78-0 2,6-dichloropyridine 
• 626-05-1 2,6-Dibromopyridine 
• 64-17-5 ethanol 

Downstream Products

• 626-06-2 2,6-dihydroxypyridine 
• 856852-72-7 2,6-diethoxy-3,5-dibromo-pyridine 

Relevant articles and documents

Novel synthesis method for ortho-alkane superseded pyridine

The invention relates to a novel synthesis method for ortho-alkane superseded pyridine. According to the method, ortho halogenated pyridine serves as raw materials, the ortho halogenated pyridine and corresponding alcohol react to obtain the ortho-alkane superseded pyridine under the action of sodium hydroxide. The reaction has universality for the ortho halogenated pyridine, and the method is simple and practical. Influence of consumption of the sodium hydroxide on mono-substitution and di-substitution in the reaction is inspected, alkoxy mono-substitution products and alkoxy di-substitution production are acquired, and a novel simply-operated, economical and favorable process for synthesis ortho-alkane superseded pyridine is provided.

Further studies of regioselective alkoxydehalogenation of 2,4-dichloroquinolines, 2,6-dichloropyridine and 2,4-dichloronitrobenzene

Regioselective alkoxydehalogenation reactions using solid alkoxide in toluene have been studied. 2-Alkoxy-4-haloquinolines were obtained from 2,4-dichloroquinolines. With 2,6-dichloropyridine, α-regioselectivity occurred to furnish the 2-alkoxy-6-chloropyridine. The reaction failed with 2,4-dichloronitrobenzene indicating that alkoxide surface contact with a basic heterocyclic nitrogen lone pair was essential for success. Comparative studies with the standard alkoxydehalogenation reaction (alcoholic alkoxide solution) have been performed, all compounds have been identified by 1H and 13C NMR.