134791-44-9

Basic information

• Product Name: Cyclopentanone, 2-[(4-chlorophenyl)methylene]-, (2E)-
• CAS NO: 134791-44-9
• Molecular Formula: C12H11ClO
• Molecular Weight: 206.672
• Mol File: 134791-44-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Cyclopentanone, 2-[(4-chlorophenyl)methylene]-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanone, 2-[(4-chlorophenyl)methylene]-, (2E)-(134791-44-9)
• EPA Substance Registry System: Cyclopentanone, 2-[(4-chlorophenyl)methylene]-, (2E)-(134791-44-9)

Safety Data

• Hazardous Substances Data: 134791-44-9(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 120-92-3 cyclopentanone 

Downstream Products

• 83236-50-4 4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione 
• 131984-21-9 5-(4-chlorobenzylidene)-2,2-dimethylcyclopentanone 
• 131984-21-9 2,2-dimethyl-5-(4-chlorobenzylidene)-1-cyclopentanone 
• 1319726-89-0 (1R,3R,4R,5R)-methyl 1,4-bis(4-chlorophenyl)-6-oxo-2-azaspiro[4.4]nonane-3-carboxylate 
• 345912-44-9 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid (4-chloro-phenyl)-amide 
• 345912-45-0 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide 
• 345912-33-6 2-[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-N-p-tolyl-acetamide 
• 345912-32-5 N-(4-chloro-phenyl)-2-[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide 

Relevant articles and documents

Ruthenium-catalysed synthesis of chiral exocyclic allylic alcoholsviachemoselective transfer hydrogenation of 2-arylidene cycloalkanones

An exclusive asymmetric reduction of C=O bonds of 2-arylidene four-, five-, six-, and seven-membered cycloalkanones has been studied systematically. The asymmetric transfer hydrogenation was performed using a robust and commercially available chiral diamine-derived ruthenium complex as a catalyst and HCOOH/Et3N as a hydrogen source under mild conditions, giving 51 examples of chiral exocyclic allylic alcohols in up to 96% yield and 99% ee. This method was also applicable to the gram-scale synthesis of the active intermediates of the anti-inflammatory loxoprofen and natural product (?)-goniomitine.

RuPHOX-Ru-Catalyzed Selective Asymmetric Hydrogenation of Exocyclic α,β-Unsaturated Pentanones

A RuPHOX-Ru catalyzed selective asymmetric hydrogenation of exocyclic α,β-unsaturated ketones has been developed, furnishing the corresponding chiral exocyclic allylic alcohols in high yields and with up to >99.5percent ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 10000 S/C) without any loss in reaction activity and enantioselectivity. The resulting hydrogenated products could be easily transformed to several biologically active compounds with high asymmetric performance. The asymmetric protocol provides an efficient methodology for the synthesis of chiral exocyclic allylic alcohols.

New and convenient approach for synthesis of metconazole

In terms of environmental and food supply protection, development of green, efficient, and less toxic pesticides is of great importance and in continuous demand. Metconazole, a triazole antiseptic, possesses such advantages, being environmentally friendly and high efficiency with broad-spectrum activity against bacteria and fungi. However, previously reported synthetic routes for metconazole have many disadvantages, for example, requiring multiple steps, being complicated, and suffering from high cost. We report herein a new, convenient, and high-yield four-step (aldol condensation, dimethylation, hydrogenation, and one-pot triazolation) synthesis for metconazole with relatively low cost.