131984-21-9Relevant articles and documents
Preparation method of metconazole (by machine translation)
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, (2019/10/01)
The method comprises the following steps: 2 - (2 - chlorobenzylidene) 2 - 2 -methylcyclopentanone and p-chlorobenzaldehyde react to obtain an epoxide; the epoxide reacts with triazole to obtain an epoxide; and the epoxide is reacted with triazole to obtain an open-loop product; and the ring-opening product 4 - is subjected -2 to 2 - catalytic hydrogenation to obtain the 2 - myclobutanil . 4 - beta-(4 -chlorbenzydrospirone; 5 -2 -5 -chlorobenzyl) 5 - and methylcyclopentanone react. Corey-Chayyyysky is obtained. The preparation method is low in cost, easy to obtain in the market; the reaction steps are all conventional reactions, reaction steps are simple, implementation; process is simple, reaction conditions are mild, operation; conversion rate is high, reaction time is short, control, and industrialization production. (by machine translation)
New and convenient approach for synthesis of metconazole
Chen, Shusheng,Zhou, Muxing,Zhang, Zhenfeng,Zhang, Wanbin
, p. 6293 - 6298 (2017/10/03)
In terms of environmental and food supply protection, development of green, efficient, and less toxic pesticides is of great importance and in continuous demand. Metconazole, a triazole antiseptic, possesses such advantages, being environmentally friendly and high efficiency with broad-spectrum activity against bacteria and fungi. However, previously reported synthetic routes for metconazole have many disadvantages, for example, requiring multiple steps, being complicated, and suffering from high cost. We report herein a new, convenient, and high-yield four-step (aldol condensation, dimethylation, hydrogenation, and one-pot triazolation) synthesis for metconazole with relatively low cost.
Design, Synthesis, and Cytotoxicity of Novel 3-Arylidenones Derived from Alicyclic Ketones
Satam, Vijay,Bandi, Ravi K.,Behera, Ajaya K.,Mishra, Bijay K.,Tzou, Samuel,Brockway, Olivia,Babu, Balaji,Zeller, Matthias,Westbrook, Cara,Mooberry, Susan L.,Lee, Moses,Pati, Hari
experimental part, p. 700 - 708 (2012/04/04)
Forty-four novel chalcone-inspired analogs having a 3-aryl-2-propenoyl moiety derived from alicyclic ketones were designed, synthesized, and investigated for cytotoxicity against murine B16 and L1210 cancer cell lines. The analogs belong to four structurally divergent series, three of which (series g, h, and i) contain differently substituted cyclopentanone units and the fourth (series j) contains a 3,3-dimethyl-4-piperidinone moiety. Of these, the analogs in series j showed potential cytotoxic activity against murine B16 (melanoma) and L1210 (lymphoma) cells. The most active compounds 5j, 11j, 15j, and 12h produced IC50 values from 4.4 to 15μm against both cell lines. A single-crystal X-ray structure analysis and molecular modeling studies confirmed that these chalcones have an E-geometry about the alkene bond and possess a slightly 'twisted' conformation similar to that of combretastatin A-4. At a concentration of 30μm, compounds 5j, 11j, and 15j did not cause microtubule depolymerization in cells, suggesting that they have a different mechanism of action. Forty-four novel chalcone-inspired analogs were designed and synthesized. Several compounds gave IC50 values 4.4-15μm against the growth of L1210 and B16 murine cancer cells.
