13518-40-6

Basic information

• Product Name: L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE
• Synonyms: L-Valine tert-butyl ester hydrochloride;(S)-tert-Butyl 2-aMino-3-Methylbutanoate hydrochloride;H-Val-OtBu·HCl L-Valine tert·butyl ester hydrochloride;L-H-Val-OtBu HCL;H-Val-OtBu;H-L-Val-OtBu Hydrochloride;L-Val-OtBu·HCl;L-Valinetert-butyl ester hydrochloride≥ 99% (HPLC)
• CAS NO: 13518-40-6
• Molecular Formula: C₉H₁₉NO₂*ClH
• Molecular Weight: 209.71
• Product Categories: Modified Amino Acids;Valine;Amino Acids and Derivatives;Amino hydrochloride;Peptide Synthesis;Amino Acid Derivatives;Amino Acids;I - ZPeptide Synthesis
• Mol File: 13518-40-6.mol

Chemical Properties

• Melting Point: 142.0 to 146.0 °C
• Boiling Point: 241.7 °C at 760 mmHg
• Flash Point: 100 °C
• Appearance: /
• Storage Temp.: Store at 0-5°C
• Solubility: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
• BRN: 3693622
• CAS DataBase Reference: L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE(13518-40-6)
• EPA Substance Registry System: L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE(13518-40-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 13518-40-6(Hazardous Substances Data)

Usage

Uses

Used in Cosmetic Formulations:
L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE is used as an active ingredient for enhancing skin health and providing essential nutrients to the skin.
Used in Pharmaceutical Applications:
L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE is used as a building block for the synthesis of various pharmaceutical compounds, contributing to the development of drugs that target specific health conditions.
Used in Animal Feed Products:
L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE is used as a supplement to provide essential amino acids necessary for the growth and overall well-being of animals.
Used in Human Nutrition:
L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE is used as a dietary supplement for promoting human growth and aiding in ammonia detoxification processes in the body.

Upstream product

• 72-18-4 L-valine 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 640-68-6 D-Val-OH 

Downstream Products

• 19794-01-5 Z-L-Val-L-Val-OtBu 
• 14470-31-6 (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-3-methylbutanoate 
• 135219-72-6 (S)-2-((R)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-butyric acid tert-butyl ester 
• 214051-85-1 (S)-2-{(S)-6-[Benzyloxycarbonyl-((S)-4-benzyloxycarbonylamino-2-hydroxy-butyl)-amino]-2-tert-butoxycarbonylamino-hexanoylamino}-3-methyl-butyric acid tert-butyl ester 
• 245364-65-2 2-(4-fluoro-benzenesulfonylamino)-3-methyl-butyric acid tert-butyl ester 
• 910630-77-2 (S)-3-Methyl-2-[(Z)-(7S,8R,9S)-7,8,9-tris-benzyloxy-9-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-non-5-enoylamino]-butyric acid tert-butyl ester 
• 13211-31-9 tert-butyl L-valinate 
• 924653-97-4 (E) N-[[2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methylene]-L-valine 1,1-dimethylethyl ester 
• 676129-94-5 (S)-3-methyl-2-((2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl)-amino)-butyric acid tert-butyl ester 
• 1158246-34-4 Z-Gly-D-Phe-L-Val-OtBu 
• 1158246-31-1 Fmoc-D-Phe-L-Val-OtBu 
• 1197342-61-2 tert-butyl ((2,4-dinitrophenyl)sulfonyl)-L-valinate 
• 1197342-71-4 FNS-L-Val-OtBu 
• 111398-44-8 N-methoxycarbonyl-L-valine 

Relevant articles and documents

Effect of substituents on enantioselectivity in chiral oxazaborolidine mediated asymmetric ketone reduction reaction

Various new chiral ligands have been synthesized by the condensation of different esters of L-Valine with different substituted salicylaldehydes in order to find the most effective catalyst for the enantioselctive ketone reduction. Chiral amine synthesized from L-Valine methyl ester and 5-chloro salicylaldehyde is found to catalyse the enantioselective reduction of prochiral ketone with high yield (99%) and enantiomeric excess (91%) with 20 mol% of the catalyst using borane dimethylsulphide as a stoichiometric reducutant. Different subsituted prochiral ketones have also been reduced in high yield upto 90% and the corresponding secondary alcohols are formed with good enantiomeric excess upto 99%. The mechanism of this reduction can be very well explained by considering a plausible mechanism for the CBS catalyst.

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STUDIES ON AMINO ACIDS AND PEPTIDES X. HPLC-MEDIATED TEST OF 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE (LAWESSONS'S REAGENT) AS A RACEMIZATIONFREE COUPLING REAGENT IN PEPTIDE SYNTHESIS

The easily available 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's Reagent), 1, has been tested as a coupling reagent for racemization in peptide synthesis.The assay procedure is separation of stereomeric products by HPLC.Z-S-Pro-S-Val-S-Pro-OtBu and Z-S-Leu-S-Phe-S-Val-OtBu have been used as test peptides in 2+1 segment couplings, and only a small amount of epimerization (0.5 and 0.1percent, respectively) has been observed.