135206-87-0

Basic information

• Product Name: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-
• CAS NO: 135206-87-0
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.185
• Mol File: 135206-87-0.mol

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-(135206-87-0)
• EPA Substance Registry System: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-(135206-87-0)

Safety Data

• Hazardous Substances Data: 135206-87-0(Hazardous Substances Data)

Usage

Uses

Used in Analytical Chemistry:
Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]is used as a reagent for various analytical chemistry applications due to its unique structural features and optical activity. Its ability to interact with different chemical species makes it a valuable tool in the development of analytical methods and techniques.
Used in Pharmacology:
In the field of pharmacology, Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its structural properties allow it to be incorporated into drug molecules, potentially enhancing their therapeutic effects and improving their pharmacokinetic profiles.
Used in Chemical Synthesis:
Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]is used as a building block in the synthesis of complex organic molecules. Its presence in the final product can influence the molecule's reactivity, stability, and overall properties, making it a valuable component in the creation of new chemical entities.
Used in Research and Development:
Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]is utilized in research and development settings to explore its potential applications and properties. Its unique characteristics make it an interesting subject for scientific investigations, which can lead to the discovery of new uses and applications in various industries.

Upstream product

• 110-91-8 morpholine 
• 17392-83-5 (R)-Methyl lactate 
• 141-78-6 ethyl acetate 
• 547-64-8 methyl lactate 

Downstream Products

• 135270-08-5 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine 
• 474010-01-0 N-((2R)-2-p-toluenosulfonyloxypropanoyl)morpholine 
• 502481-62-1 2-((S)-1-morpholinocarbonylethoxy)-4-hydroxymethylnitrobenzene 
• 502481-64-3 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylaniline 
• 502481-63-2 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene 
• 502481-65-4 methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate 
• 900183-42-8 4-((2R)-2-{[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)benzyl]oxy}propanoyl)morpholine 
• 940009-00-7 2-chloro-4-({5-[(1R)-1-methyl-2-morpholin-4-yl-2-oxoethoxy]quinazolin-4-yl}amino)phenol 
• 900183-29-1 4-{(2R)-2-[(3-bromobenzyl)oxy]propanoyl}morpholine 
• 247196-89-0 (R)-2-benzyloxypropionyl N-morpholinyl amide 

Relevant articles and documents

Triazole alcohol derivative as well as preparation method and application thereof

The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.

Triazole alcohol derivative, and preparation method and application thereof

The invention relates to a triazole alcohol derivative, and a preparation method and an application thereof. The chemical structure of the triazole alcohol derivative is represented by formula I, A inthe formula I represents a benzene ring or a substituted benzene ring, and the substituent group of the substituted benzene ring can be located at each position of the benzene ring, is monosubstituted or polysubstituted, and is selected from: a) halogen which is F, Cl, Br or I; b) an electron-withdrawing group, wherein the electron withdrawing group is a cyano group, a nitro group or a trifluoromethyl group; c) a C1-4 low alkyl group or a halogen-substituted low alkyl group; and d) a C1-4 low alkoxy group or a halogen-substituted low alkoxy group. The compound has the advantages of high antifungal activity, low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal medicines.

A PROCESS FOR THE PREPARATION OF ISAVUCONAZOLE AND ITS INTERMEDIATES

The present invention relates to a process for the preparation of Isavuconazole or its pharmaceutical acceptable salt thereof. In particular aspects of the present invention relates to a process for the preparation of intermediate of azole intermediate. In a further aspect, the present invention relates to a process for the preparation of triazole intermediate. In a further aspect, the present invention relates to a process for the preparation of oxirane intermediate.

Enantioselective organocatalytic rearrangement of α-acyloxy- β-keto sulfides to α-acyloxy thioesters

The first highly enantioselective organocatalytic rearrangement of α-acyloxy-β-keto sulfides to α-acyloxy thioesters has been developed which provides a number of important synthetic building blocks in high yield and with excellent enantioselectivities (e

The process development of ravuconazole: An efficient multikilogram scale preparation of an antifungal agent

The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demonstration through plant scale preparations are presented. A controlled means to prepare a Grignard reagent and utilization of Fourier Transform Infrared spectroscopy (FTIR) monitoring to safely conduct the reaction is featured.

Discovery of novel indazole-linked triazoles as antifungal agents

The in vitro and in vivo activities of a series of (2R, 3R)-2-(2,4-difluorophenyl)-3-(substituted indazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol as potential antifungal agents are described. In particular, the analog 12j having 5-bromo substitution on the indazole ring exhibited significant antifungal activity against a variety of fungal cultures (Candida spp. and Aspergillus spp.). In addition, oral administration of 12j showed its excellent efficacy against Candida albicans in a murine infection model and the significantly improved survival rates of the infected mice.

NOVEL HETEROARYL DERIVATIVE

A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.

NOVEL HETEROARYL DERIVATIVE

A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. (1) wherein: the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl, etc.

ANTIFUNGAL AZOLE DERIVATIVES HAVING A FLUOROVINYL MOIETY AND PROCESS FOR THE PREPARATION THEREOF

An azole derivative of formula (I) having a fluorovinyl moiety or a pharmaceutically acceptable salt thereof is superior to the conventional antifungal drugs in antifungal activity against a wide spectrum of pathogenic fungi, and has advantageously low toxicity.

PYRROLE DERIVATIVE

A novel pyrrole derivative represented by the following formula (1) and a salt thereof: wherein R1 means substituted alkenyl, etc.; R2 means substituted benzoyl, etc.; and R3 to R5 each means hydrogen, alkyl, halogeno, etc. The derivative and salt have antidiabetic activity.