135904-71-1

Basic information

• Product Name: H-D-Asp(OtBu)-OtBu · HCl
• Synonyms: D-Aspartic acid 1,4-di-tert-butyl ester hydrochloride;H-D-Asp(tBu)-OtBu Hydrochloride;D-Aspartic acid bis(1,1-dimethylethyl) ester hydrochloride;D-Asp(OtBu)-OtBu·HCl;D-Aspartic acid 1,4-di-t-butyl ester hydrochloride;H-D-Asp(tBu)-OtBu*HCl;H-D-Asp(OBut)-OButl.HCl;(R)-Di-tert-butyl 2-aMinosuccinate hydrochloride
• CAS NO: 135904-71-1
• Molecular Formula: C₁₂H₂₃NO₄*ClH
• Molecular Weight: 0
• Mol File: 135904-71-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: H-D-Asp(OtBu)-OtBu · HCl(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Asp(OtBu)-OtBu · HCl(135904-71-1)
• EPA Substance Registry System: H-D-Asp(OtBu)-OtBu · HCl(135904-71-1)

Safety Data

• Hazardous Substances Data: 135904-71-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
H-D-Asp(OtBu)-OtBu · HCl is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, facilitating the formation of new compounds and structures.
Used in Peptide Synthesis:
In the pharmaceutical and biotechnology industries, H-D-Asp(OtBu)-OtBu · HCl is used as a building block for the synthesis of peptides. Its incorporation into peptide sequences allows for the creation of bioactive molecules with specific functions and properties.
Used in Chemical Research:
H-D-Asp(OtBu)-OtBu · HCl is utilized in chemical research to study the properties and reactivity of aspartic acid derivatives and their potential applications in various fields, such as drug development and materials science.

InChI:InChI=1/C12H23NO4.ClH/c1-11(2,3)16-9(14)7-8(13)10(15)17-12(4,5)6;/h8H,7,13H2,1-6H3;1H/t8-;/m1./s1

Upstream product

• 13795-73-8 L-aspartic acid di-tert-butyl ester 
• 540-88-5 acetic acid tert-butyl ester 
• 42417-76-5 1,4-di-tert-butyl (2S)-2-{[(benzyloxy)carbonyl]amino}butanedioate 

Downstream Products

• 103777-98-6 N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester 
• 3057-74-7 L-Asp(t-Bu) 
• 87085-11-8 H-Tyr-Asp-OH 
• 438246-17-4 C₁₉H₂₆N₂O₈ 
• 280777-76-6 L-N-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetyl]aspartic acid 
• 1262887-73-9 (2S,2'S)-tetra-tert-butyl 2,2'-((5-nitroisophthaloyl)bis(azanediyl))disuccinate 
• 1262887-75-1 (2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate 
• 1262887-74-0 (2S,2'S)-tetra-tert-butyl 2,2'-((5-aminoisophthaloyl)bis(azanediyl))disuccinate 
• 1299464-04-2 2-(4-vinyl-benzoylamino)-succinic acid di-tert-butyl ester 
• 1370418-69-1 (S)-di-tert-butyl 2-{3-[(1R,2R)-2-amino-1,2-diphenylethyl]thioureido}succinate 
• 1370418-71-5 (S)-di-tert-butyl 2-{3-[(1R,2R)-2-aminocyclohexyl]thioureido}succinate 
• 1370418-73-7 (S)-di-tert-butyl 2-{3-[(1R,2R)-2-(dimethylamino)-1,2-diphenylethyl]thioureido}succinate 
• 1432474-25-3 C₃₅H₄₁NO₁₇ 
• 1469273-30-0 C₂₁H₂₅F₆NO₅ 

Relevant articles and documents

Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

A series of analogues of the integrin binding aspartic acid-glycine-arginine (RGD) peptide sequence were synthesised conjugated to nitric oxide (NO) donating functional groups. Also the cytotoxicity of abiraterone, a prostate cancer drug, was explored when it was conjugated in three part constructs to RGD sequences and NO releasing heterocycles. In general the analogues showed integrin binding affinity comparable to RGD reference compounds, and all released NO by the Griess test assay. Two analogues exhibited significant cytotoxic effects against PC3 and MCF7 cell lines.

Preparation of protected amino acids

The present invention involves a process for preparing protected amino acids. The process produces a di-tert-butyl amino ester or an N-protected di-tert-butyl amino ester by transesterification of an acidic amino acid or an N-protected acidic amino acid. By-products of the transesterification reaction may be recycled for use as part of the starting material. The N-protected di-tert-butyl amino ester may be hydrogenated to form a di-tert-butyl amino ester, which may subsequently form a di-tert-butyl ester hydrocholride salt.