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(R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole is a chemical compound belonging to the class of triazoles, characterized by its potent antifungal properties and a unique molecular structure featuring difluorophenyl and tetrahydrofuran moieties.

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  • (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole

    Cas No: 1370190-85-4

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  • 1370190-85-4 Structure
  • Basic information

    1. Product Name: (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole
    2. Synonyms: (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole
    3. CAS NO:1370190-85-4
    4. Molecular Formula:
    5. Molecular Weight: 277.274
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1370190-85-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole(1370190-85-4)
    11. EPA Substance Registry System: (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole(1370190-85-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1370190-85-4(Hazardous Substances Data)

1370190-85-4 Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole is used as an antifungal agent for the treatment of various fungal infections. Its application is based on its ability to inhibit the synthesis of ergosterol, a vital component of the fungal cell membrane, which leads to the disruption of membrane integrity and the subsequent death of fungal cells.
Used in Agricultural Industry:
In addition to its pharmaceutical applications, (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole also shows potential as a fungicide in the agricultural sector. It is utilized to protect crops from a wide range of fungal diseases, ensuring the health and productivity of the plants. (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole's effectiveness against various fungal pathogens makes it a valuable asset in crop protection and management.

Check Digit Verification of cas no

The CAS Registry Mumber 1370190-85-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,0,1,9 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1370190-85:
(9*1)+(8*3)+(7*7)+(6*0)+(5*1)+(4*9)+(3*0)+(2*8)+(1*5)=144
144 % 10 = 4
So 1370190-85-4 is a valid CAS Registry Number.

1370190-85-4Downstream Products

1370190-85-4Relevant articles and documents

Enantioselective synthesis of 2,2-disubstituted tetrahydrofurans: Palladium-catalyzed [3+2] cycloadditions of trimethylenemethane with ketones

Trost, Barry M.,Bringley, Dustin A.

, p. 4466 - 4469 (2013)

O rings: An approach to the title compounds has been developed utilizing a cycloaddition of trimethylenemethane with aryl ketones. The products are formed in up to a 96 % yield with 95 % ee. The reaction is catalyzed by palladium in the presence of L1, which possesses a stereogenic phosphorus atom, and only a single epimer at the phosphorus atom yields the active catalyst. Cp=cyclopentadiene, TMS=trimethylsilyl. Copyright

ANTIMYCOTIC TRIAZOLE COMPOUND

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Page/Page column 3; 13, (2017/07/08)

The invention relates to Compound (I), which is 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)-N-(4-fluorophenyl)benzamide, or a pharmaceutically acceptable salt thereof, usefu

ANTIMYCOTIC COMPOUND

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Page/Page column 16, (2016/06/28)

This invention relates to a compound, as defined in the specification, useful in the treatment of mycoses, compositions containing it and its use in therapy.

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