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CAS

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137736-63-1

2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine is a pyridine derivative with the molecular formula C12H7BrF3NO. It features a pyridine ring with a bromophenoxy group at position 2 and a trifluoromethyl group at position 5. This chemical compound is utilized in various scientific and industrial applications.

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  • 137736-63-1 Structure

  • Basic information

    1. Product Name: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine
    2. Synonyms: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine
    3. CAS NO:137736-63-1
    4. Molecular Formula: C12H7BrF3NO
    5. Molecular Weight: 318.0892896
    6. EINECS: N/A
    7. Product Categories: Halides;Phenyls & Phenyl-Het
    8. Mol File: 137736-63-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 328.5±37.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.567±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Inert atmosphere,Room Temperature
    8. Solubility: N/A
    9. PKA: 0.18±0.22(Predicted)
    10. CAS DataBase Reference: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine(137736-63-1)
    12. EPA Substance Registry System: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine(137736-63-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 137736-63-1(Hazardous Substances Data)

137736-63-1 Usage

Uses

Used in Pharmaceutical Industry:
2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine is used as a building block for the synthesis of pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, potentially leading to advancements in medicine.
Used in Agrochemical Industry:
In the agrochemical field, 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine serves as a building block for the synthesis of agrochemicals. It contributes to the creation of substances that can improve agricultural productivity and crop protection.
Used in Organic Compound Production:
2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine is used as an intermediate in the production of organic compounds. Its specific chemical properties make it valuable for synthesizing a range of organic substances used across different industries.
Used as a Chemical Reaction Reagent:
2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine also functions as a reagent in chemical reactions. Its role in these processes is essential for the development of new materials and substances in various fields, including chemistry, medicine, and agriculture.

Check Digit Verification of cas no

The CAS Registry Mumber 137736-63-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,7,3 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 137736-63:
(8*1)+(7*3)+(6*7)+(5*7)+(4*3)+(3*6)+(2*6)+(1*3)=151
151 % 10 = 1
So 137736-63-1 is a valid CAS Registry Number.

137736-63-1Relevant articles and documents

Discovery, synthesis, and optimization of antimalarial 4(1 H)-quinolone-3-diarylethers

Nilsen, Aaron,Miley, Galen P.,Forquer, Isaac P.,Mather, Michael W.,Katneni, Kasiram,Li, Yuexin,Pou, Sovitj,Pershing, April M.,Stickles, Allison M.,Ryan, Eileen,Kelly, Jane Xu,Doggett, J. Stone,White, Karen L.,Hinrichs, David J.,Winter, Rolf W.,Charman, Susan A.,Zakharov, Lev N.,Bathurst, Ian,Burrows, Jeremy N.,Vaidya, Akhil B.,Riscoe, Michael K.

, p. 3818 - 3834 (2014/05/20)

The historical antimalarial compound endochin served as a structural lead for optimization. Endochin-like quinolones (ELQ) were prepared by a novel chemical route and assessed for in vitro activity against multidrug resistant strains of Plasmodium falciparum and against malaria infections in mice. Here we describe the pathway to discovery of a potent class of orally active antimalarial 4(1H)-quinolone-3-diarylethers. The initial prototype, ELQ-233, exhibited low nanomolar IC50 values against all tested strains including clinical isolates harboring resistance to atovaquone. ELQ-271 represented the next critical step in the iterative optimization process, as it was stable to metabolism and highly effective in vivo. Continued analoging revealed that the substitution pattern on the benzenoid ring of the quinolone core significantly influenced reactivity with the host enzyme. This finding led to the rational design of highly selective ELQs with outstanding oral efficacy against murine malaria that is superior to established antimalarials chloroquine and atovaquone.

Aryl Substituted Indoles and Their Use as Blockers of Sodium Channels

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Paragraph 0493; 0494; 0585, (2013/11/19)

The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

HETEROARYL COMPOUNDS AS SODIUM CHANNEL BLOCKERS

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Paragraph 0315, (2013/05/22)

The invention relates to aryl substituted compounds of Formula (I) : and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein Het, G, A, R, and n are defined as set forth in the specification. The invention is also directed to the use

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