100366-75-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Iodo-5-trifluoromethylpyridine is used as a building block for the synthesis of pharmaceutical compounds. Its unique structure and reactivity contribute to the development of new molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Iodo-5-trifluoromethylpyridine serves as a building block for the synthesis of agrochemical compounds. Its properties enable the creation of new molecules with potential applications in agriculture, such as pesticides or herbicides.
Used as a Reagent in Organic Synthesis:
2-Iodo-5-trifluoromethylpyridine is utilized as a reagent in organic synthesis, particularly in the preparation of heterocyclic compounds. Its versatility and properties make it a valuable chemical in research and industrial applications, facilitating the synthesis of complex molecules with diverse functionalities.

InChI:InChI=1/C6H3F3IN/c7-6(8,9)4-1-2-5(10)11-3-4/h1-3H

Upstream product

• 55304-75-1 2,6-dichloro-3-(trifluoromethyl)pyridine 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 75-36-5 acetyl chloride 

Downstream Products

• 80194-69-0 5-(trifluoromethyl)picolinic acid 
• 95727-86-9 2-cyano-5-trifluoro-methylpyridine 
• 31181-84-7 2-hydroxymethyl-5-trifluoromethylpyridine 
• 128790-14-7 5-trifluoromethyl-pyridin-2-ylmethyl chloride 
• 31224-82-5 5-(trifluoromethyl)pyridine-2-carbaldehyde 
• 137736-63-1 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine 
• 1355052-60-6 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine 
• 1599467-89-6 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline 
• 1354745-74-6 6-chloro-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinolin-4(1H)-one 
• 1000773-62-5 2-(bromomethyl)-5-(trifluoromethyl)pyridine 
• 1093742-84-7 C₁₈H₁₇F₃N₂ 

Relevant academic research and scientific papers

Fine-tuning the oxidative ability of persistent radicals: Electrochemical and computational studies of substituted 2-pyridylhydroxylamines

N-tert-Butyl-N-2-pyridylhydroxylamines were synthesized from 2-halopyridines and 2-methyl-2-nitrosopropane using magnesium-halogen exchange. The use of Turbo Grignard generated the metallo-2-pyridyl intermediate more reliably than alkyllithium reagents. The hydroxylamines were characterized using NMR, electrochemistry, and density functional theory. Substitution of the pyridyl ring in the 3-, 4-, and 5-positions was used to vary the potential of the nitroxyl/oxoammonium redox couple by 0.95 V. DFT computations of the electrochemical properties agree with experiment and provide a toolset for the predictive design of pyridyl nitroxides.

Oxadiazolopyridine Derivates for Use as Ghrelin O-Acyl Transferase (GOAT) Inhibitors

The present invention relates to compounds of general formula I, wherein the groups R1, R2 and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.

Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids

As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

Synthesis of thieno[2,3-b]quinoxalines from 2-haloquinoxalines

Thieno[2,3-b]quinoxalines were synthesized from 2-haloquinoxalines using palladium catalyst. The coupling of latter with alkynes and addition of one mol equivalent of bromine to the 2-alkynylquinoxalines thus produced was described. The resulting dibromid