138163-08-3

Basic information

• Product Name: 4-FORMYL-N-CBZ-PIPERIDINE
• Synonyms: 4-FORMYL-N-CBZ-PIPERIDINE;4-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;BUTTPARK 92\50-59;BENZYL 4-FORMYLTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;N-CBZ-4-PIPERIDINYLCARBOXALDEHYDE;N-CBZ-4-FORMYLPIPERIDINE;Piperidine-4-carboxaldehyde, N-CBZ protected;Benzyl 4-formyltetrahydro-1(2H)-pyridinecarboxylate, 90+%
• CAS NO: 138163-08-3
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.29
• Product Categories: Carbonyl Compounds;Heterocycles
• Mol File: 138163-08-3.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 384.5 °C at 760 mmHg
• Flash Point: 186.3 °C
• Appearance: /
• Density: 1.221 g/cm³
• Vapor Pressure: 4.07E-06mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.18±0.40(Predicted)
• CAS DataBase Reference: 4-FORMYL-N-CBZ-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FORMYL-N-CBZ-PIPERIDINE(138163-08-3)
• EPA Substance Registry System: 4-FORMYL-N-CBZ-PIPERIDINE(138163-08-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• Hazardous Substances Data: 138163-08-3(Hazardous Substances Data)

Usage

Uses

4-Formyl-N-Cbz-piperidine is a useful reagent for the preparation of pyrimidinyltetrahydropyridoindoles as estrogen receptor degrading PROTACs.

InChI:InChI=1/C14H17NO3/c16-10-12-6-8-15(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,10,12H,6-9,11H2

Upstream product

• 148148-48-5 4-(N-methoxy-N-methyl-carbamoyl)-piperidine-1-carboxylic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 
• 160809-38-1 1-benzyl 4-ethyl piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 122860-33-7 benzyl 4-(hydroxymethyl)piperidine-N-carboxylate 
• 10314-99-5 benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate 
• 138163-07-2 piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-methyl ester 
• 6457-49-4 4-piperidinemethanol 
• 87413-09-0 Dess-Martin periodane 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1056629-32-3 3-Azaspiro[5.5]undecan-9-one 
• 396073-62-4 4-((E)-5-Methoxycarbonyl-pent-1-enyl)-piperidine-1-carboxylic acid benzyl ester 
• 866929-65-9 4-(2,2,2-trifluoro-1-hydroxy-ethyl)-piperidine-1-carboxylic acid benzyl ester 
• 918421-64-4 1'-(benzyloxycarbonyl)-1,2-dihydro-5-t-butylspiro[3H-indole-3,4'-piperidine] 
• 1200575-51-4 benzyl 4-(6-bromo-4H-1,3-benzodioxin-2-yl)piperidine-1-carboxylate 
• 184289-85-8 benzyl spiro[indole-3,4'-piperidine]-1'-carboxylate 
• 527693-82-9 3-[N-(benzyloxycarbonylpiperidin-4-yl)]propenoic acid 
• 633312-74-0 C₂₆H₃₂N₄O₃ 

Relevant articles and documents

Drastic fluorine effect: Complete reversal of the selectivity in the Au-catalyzed hydroalkoxylation reaction of fluorinated haloalkynes

The gold-catalyzed hydration reaction of haloalkynes is highly regioselective producing 2-halomethylketones as the sole products. Herein, we document a drastic fluorine effect where the reaction of 1-halo-3,3-difluoroalkynes as substrates leads to a complete reversal of selectivity and produces 3,3-difluoroesters as the unique products.

Highly regioselective gold-catalyzed formal hydration of propargylic: Gem -difluorides

Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a highly regioselective gold-catalyzed hydroalkoxylation of internal alkynes and puts forward the utility of the difluoromethylene unit as a directing group in catalysis.

SULFONAMIDE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR MODULATORS AND USES THEREOF

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of Retinoic Acid Receptor-Related Orphan Receptor regulated diseases and disorders.